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This is generally accompanied by a reduction in traits attracting pollinators, including reduced emission of floral scent. In\n                          <jats:italic>Capsella<\/jats:italic>\n                          , emission of benzaldehyde as a main component of floral scent has been lost in selfing\n                          <jats:italic>C.\u00a0rubella<\/jats:italic>\n                          by mutation of cinnamate\u2010CoA ligase\n                          <jats:styled-content style=\"fixed-case\">CNL<\/jats:styled-content>\n                          1. However, the biochemical basis and evolutionary history of this loss remain unknown, as does the reason for the absence of benzaldehyde emission in the independently derived selfer\n                          <jats:italic>Capsella orientalis<\/jats:italic>\n                          .\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          We used plant transformation,\n                          <jats:italic>in vitro<\/jats:italic>\n                          enzyme assays, population genetics and quantitative genetics to address these questions.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          <jats:styled-content style=\"fixed-case\">CNL<\/jats:styled-content>\n                          1 has been inactivated twice independently by point mutations in\n                          <jats:italic>C.\u00a0rubella<\/jats:italic>\n                          , causing a loss of enzymatic activity. Both inactive haplotypes are found\u00a0within and outside of\u00a0Greece, the centre of origin of\n                          <jats:italic>C.\u00a0rubella<\/jats:italic>\n                          , indicating that they arose before its geographical spread. By contrast, the loss of benzaldehyde emission in\n                          <jats:italic>C.\u00a0orientalis<\/jats:italic>\n                          is not due to an inactivating mutation in\n                          <jats:italic>\n                            <jats:styled-content style=\"fixed-case\">CNL<\/jats:styled-content>\n                            1\n                          <\/jats:italic>\n                          .\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          <jats:italic>\n                            <jats:styled-content style=\"fixed-case\">CNL<\/jats:styled-content>\n                            1\n                          <\/jats:italic>\n                          represents a hotspot for mutations that eliminate benzaldehyde emission, potentially reflecting the limited pleiotropy and large effect of its inactivation. Nevertheless, even closely related species have followed different evolutionary routes in reducing floral scent.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1111\/nph.16103","type":"journal-article","created":{"date-parts":[[2019,8,10]],"date-time":"2019-08-10T08:54:50Z","timestamp":1565427290000},"page":"1349-1360","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Retracing the molecular basis and evolutionary history of the loss of benzaldehyde emission in the genus\n                    <i>Capsella<\/i>"],"prefix":"10.1111","volume":"224","author":[{"given":"Friederike","family":"Jantzen","sequence":"first","affiliation":[{"name":"Institute for Biochemistry and Biology University of Potsdam Karl\u2010Liebknecht\u2010Stra\u00dfe 24\u201325 D\u201014476 Potsdam\u2010Golm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0685-1562","authenticated-orcid":false,"given":"Joseph H.","family":"Lynch","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Purdue University 175 South University St. West Lafayette IN 47907\u20102063 USA"},{"name":"Purdue Center for Plant Biology Purdue University West Lafayette IN 47907 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1450-1864","authenticated-orcid":false,"given":"Christian","family":"Kappel","sequence":"additional","affiliation":[{"name":"Institute for Biochemistry and Biology University of Potsdam Karl\u2010Liebknecht\u2010Stra\u00dfe 24\u201325 D\u201014476 Potsdam\u2010Golm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jona","family":"H\u00f6fflin","sequence":"additional","affiliation":[{"name":"Institute of Biology Dahlem Centre of Plant Sciences (DCPS) Freie Universit\u00e4t Berlin Haderslebener Stra\u00dfe 9 12163 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oded","family":"Skaliter","sequence":"additional","affiliation":[{"name":"Robert H. Smith Faculty of Agriculture, Food and Environment The Hebrew University of Jerusalem PO Box 12 76100 Rehovot Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9131-0666","authenticated-orcid":false,"given":"Natalia","family":"Wozniak","sequence":"additional","affiliation":[{"name":"Institute for Biochemistry and Biology University of Potsdam Karl\u2010Liebknecht\u2010Stra\u00dfe 24\u201325 D\u201014476 Potsdam\u2010Golm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4104-6844","authenticated-orcid":false,"given":"Adrien","family":"Sicard","sequence":"additional","affiliation":[{"name":"Institute for Biochemistry and Biology University of Potsdam Karl\u2010Liebknecht\u2010Stra\u00dfe 24\u201325 D\u201014476 Potsdam\u2010Golm Germany"},{"name":"Department of Plant Biology Uppsala BioCenter Swedish University of Agricultural Sciences and Linnean Center for Plant Biology Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Sas","sequence":"additional","affiliation":[{"name":"Institute for Biochemistry and Biology University of Potsdam Karl\u2010Liebknecht\u2010Stra\u00dfe 24\u201325 D\u201014476 Potsdam\u2010Golm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1288-0944","authenticated-orcid":false,"given":"Funmilayo","family":"Adebesin","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Purdue University 175 South University St. West Lafayette IN 47907\u20102063 USA"},{"name":"Purdue Center for Plant Biology Purdue University West Lafayette IN 47907 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmin","family":"Ravid","sequence":"additional","affiliation":[{"name":"Robert H. 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