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In local basal resistance, <jats:styled-content style=\"fixed-case\">CPK<\/jats:styled-content>5 functions upstream of <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content> synthesis, perception, and signaling. In systemic tissue, <jats:styled-content style=\"fixed-case\">CPK<\/jats:styled-content>5 signaling leads to accumulation of <jats:styled-content style=\"fixed-case\">SAR<\/jats:styled-content>\u2010inducing metabolite <jats:italic>N<\/jats:italic>\u2010hydroxy\u2010<jats:sc>L<\/jats:sc>\u2010pipecolic acid (<jats:styled-content style=\"fixed-case\">NHP<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">SAR<\/jats:styled-content> marker genes, including <jats:italic>Systemic Acquired Resistance Deficient 1<\/jats:italic> (<jats:italic><jats:styled-content style=\"fixed-case\">SARD<\/jats:styled-content>1)<\/jats:italic><\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Plants of increased <jats:styled-content style=\"fixed-case\">CPK<\/jats:styled-content>5, but not <jats:styled-content style=\"fixed-case\">CPK<\/jats:styled-content>6, signaling display an \u2018enhanced <jats:styled-content style=\"fixed-case\">SAR<\/jats:styled-content>\u2019 phenotype towards a secondary bacterial infection. In the <jats:italic>sard1\u20101<\/jats:italic> background, <jats:styled-content style=\"fixed-case\">CPK<\/jats:styled-content>5\u2010mediated basal resistance is still mounted, but <jats:styled-content style=\"fixed-case\">NHP<\/jats:styled-content> concentration is reduced and enhanced <jats:styled-content style=\"fixed-case\">SAR<\/jats:styled-content> is lost.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>The biochemical analysis estimated <jats:styled-content style=\"fixed-case\">CPK<\/jats:styled-content>5 half maximal kinase activity for calcium, K50 [Ca<jats:sup>2+<\/jats:sup>], to be <jats:italic>c<\/jats:italic>.\u00a0100\u00a0nM, close to the cytoplasmic resting level. This low threshold uniquely qualifies <jats:styled-content style=\"fixed-case\">CPK<\/jats:styled-content>5 to decode subtle changes in calcium, a prerequisite to signal relay and onset and maintenance of priming at later time points in distal tissue. Our data explain why <jats:styled-content style=\"fixed-case\">CPK<\/jats:styled-content>5 functions as a hub in basal and systemic plant immunity.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/nph.16147","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T18:24:46Z","timestamp":1567189486000},"page":"310-325","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Calcium\u2010dependent protein kinase 5 links calcium signaling with <i>N<\/i>\u2010hydroxy\u2010<scp>l<\/scp>\u2010pipecolic acid\u2010 and <i><scp>SARD<\/scp>1<\/i>\u2010dependent immune memory in systemic acquired resistance"],"prefix":"10.1111","volume":"225","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0199-7354","authenticated-orcid":false,"given":"Tiziana","family":"Guerra","sequence":"first","affiliation":[{"name":"Department of Plant Biochemistry Dahlem Centre of Plant Sciences 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