{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:32:25Z","timestamp":1792024345184,"version":"4.4.0"},"reference-count":70,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T00:00:00Z","timestamp":1572480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31561130154"],"award-info":[{"award-number":["31561130154"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["nph.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["New Phytologist"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>\n<jats:list list-type=\"bullet\">\n\n<jats:list-item><jats:p>Uniform growth of the main shoot and tillers significantly influences rice plant architecture and grain yield. The WUSCHEL\u2010related homeobox transcription factor <jats:italic>DWT1<\/jats:italic> is a key regulator of this important agronomic trait, disruption of which causes enhanced main shoot dominance and tiller dwarfism by an unknown mechanism.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Here, we have used yeast\u2010two\u2010hybrid screening to identify OsPIP5K1<jats:italic>,<\/jats:italic> a member of the rice phosphatidylinositol\u20104\u2010phosphate 5\u2010kinase family, as a protein that interacts with DWT1. Cytological analyses confirmed that DWT1 induces accumulation of OsPIP5K1 and its product PI(4,5)P<jats:sub>2<\/jats:sub>, a phosphoinositide secondary messenger, in nuclear bodies.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Mutation of OsPIP5K1 compounds the dwarf <jats:italic>dwt1<\/jats:italic> phenotype but abolishes the main shoot dominance. Conversely, overexpression of <jats:italic>OsPIP5K1<\/jats:italic> partially rescues <jats:italic>dwt1<\/jats:italic> developmental defects. Furthermore, we showed that DWL2, the homologue of DWT1, is also able to interact with OsPIP5K1 and shares partial functional redundancy with DWT1 in controlling rice uniformity.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Overall, our data suggest that nuclear localised OsPIP5K1 acts with DWT1 and\/or DWL2 to coordinate the uniform growth of rice shoots, likely to be through nuclear phosphoinositide signals, and provides insights into the regulation of rice uniformity via a largely unexplored plant nuclear signalling pathway.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/nph.16216","type":"journal-article","created":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T17:31:49Z","timestamp":1569346309000},"page":"1234-1246","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["DWT1\/DWL2 act together with OsPIP5K1 to regulate plant uniform growth in 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