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Although a growing body of evidence indicates that DNA damage is one of the prime drivers of aging in animals, little is known regarding the importance of DNA damage and its repair on lifespan control in plants.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>We found that the level of DSBs increases but DNA repair efficiency decreases as <jats:italic>Arabidopsis<\/jats:italic> leaves age. Generation of DSBs by inducible expression of I<jats:italic>\u2010Ppo<\/jats:italic>I leads to premature senescence phenotypes.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>We examined the senescence phenotypes in the loss\u2010of\u2010function mutants for 13 key components of the DNA repair pathway and found that deficiency in ATAXIA TELANGIECTASIA MUTATED (ATM), the chief transducer of the DSB signal, results in premature senescence in <jats:italic>Arabidopsis<\/jats:italic>. ATM represses DSB\u2010induced expression of senescence\u2010associated genes, including the genes encoding the WRKY and NAC transcription factors, central components of the leaf senescence process, via modulation of histone lysine methylation.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Our work highlights the significance of ATM in the control of leaf senescence and has significant implications for the conservation of aging mechanisms in animals and plants.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/nph.16535","type":"journal-article","created":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T17:11:43Z","timestamp":1584033103000},"page":"473-484","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["ATM suppresses leaf senescence triggered by DNA double\u2010strand break through epigenetic control of senescence\u2010associated genes in 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