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However, the underlying mechanism remains to be fully established.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>The molecular and cellular functions of ANGUSTIFOLIA (AN) were characterised, and its role in regulating the pathogenic response was studied in Arabidopsis.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>We demonstrated that AN, a plant homologue of mammalian C\u2010TERMINAL BINDING PROTEIN (CtBP), antagonistically regulates plant resistance to the hemibiotrophic pathogen <jats:italic>Pseudomonas syringae<\/jats:italic> and the necrotrophic pathogen <jats:italic>Botrytis cinerea<\/jats:italic>. Consistent with phenotypic observations, transcription of genes involved in SA and JA\/ET pathways was antagonistically regulated by AN. By interacting with another nuclear protein TYROSYL\u2010DNA PHOSPHODIESTERASE1 (TDP1), AN imposes transcriptional repression on <jats:italic>MYB46<\/jats:italic>, encoding a transcriptional activator of <jats:italic>PHENYLALANINE AMMONIA\u2010LYASE<\/jats:italic> (<jats:italic>PAL<\/jats:italic>) genes which are required for SA biosynthesis, while releasing TDP1\u2010imposed transcriptional repression on <jats:italic>WRKY33<\/jats:italic>, a master regulator of the JA\/ET signalling pathway.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>These findings demonstrate that transcriptional co\u2010regulation of <jats:italic>MYB46<\/jats:italic> and <jats:italic>WRKY33<\/jats:italic> by AN mediates the coordination of SA and JA\/ET pathways to optimise defences against (hemi)biotrophic and necrotrophic pathogens.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/nph.16826","type":"journal-article","created":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T13:26:20Z","timestamp":1595597180000},"page":"1627-1639","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Arabidopsis C\u2010terminal binding protein ANGUSTIFOLIA modulates transcriptional co\u2010regulation of <i>MYB46<\/i> and <i>WRKY33<\/i>"],"prefix":"10.1111","volume":"228","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0247-3701","authenticated-orcid":false,"given":"Meng","family":"Xie","sequence":"first","affiliation":[{"name":"Biosciences Division Oak Ridge National Laboratory Oak Ridge TN 37831 USA"},{"name":"BioEnergy Science Center Oak Ridge National Laboratory Oak Ridge TN 37831 USA"},{"name":"Center for Bioenergy Innovation Oak Ridge National Laboratory Oak Ridge TN 37831 USA"},{"name":"Department of Plant Sciences 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