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Analysing the role of effectors in altering the function of their host target proteins will reveal critical components of the plant immune system.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          Here we show that\n                          <jats:italic>Phytophthora infestans<\/jats:italic>\n                          RXLR effector PITG20303, a virulent variant of AVRblb2 (PITG20300) that escapes recognition by the resistance protein Rpi\u2010blb2, suppresses PAMP\u2010triggered immunity (PTI) and promotes pathogen colonization by targeting and stabilizing a potato MAPK cascade protein, StMKK1. Both PITG20300 and PITG20303 target StMKK1, as confirmed by multiple\n                          <jats:italic>in vivo<\/jats:italic>\n                          and\n                          <jats:italic>in vitro<\/jats:italic>\n                          assays, and\n                          <jats:italic>StMKK1<\/jats:italic>\n                          was shown to be a negative regulator of plant immunity, as determined by overexpression and gene silencing.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          <jats:italic>StMKK1<\/jats:italic>\n                          is a negative regulator of plant PTI, and the kinase activities of StMKK1 are required for its suppression of PTI and effector interaction. PITG20303 depends partially on MKK1, PITG20300 does not depend on MKK1 for suppression of PTI\u2010induced reactive oxygen species burst, while the full virulence activities of nuclear targeted PITG20303 and PITG20300 are dependent on MKK1.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Our results show that PITG20303 and PITG20300 target and stabilize the plant MAPK cascade signalling protein StMKK1 to negatively regulate plant PTI response.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1111\/nph.16861","type":"journal-article","created":{"date-parts":[[2020,8,9]],"date-time":"2020-08-09T12:20:42Z","timestamp":1596975642000},"page":"501-515","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":99,"title":["<i>Phytophthora infestans<\/i>\n           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