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To date, few studies have reported the existence of histone modification in maintaining the Fe\u2010deficiency response. However, the reports that do exist shed light on various histone modifications, but knowledge of the activation mark in Fe\u2010deficiency response is lacking.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>By using a forward genetics approach, we identified a crucial allele for Fe\u2010deficiency response, <jats:italic>NON\u2010RESPONSE TO Fe\u2010DEFICIENCY2<\/jats:italic> (<jats:italic>NRF2<\/jats:italic>), previously described as <jats:italic>EARLY FLOWERING8<\/jats:italic> (<jats:italic>ELF8<\/jats:italic>) associated with an activation mark on histone modification, histone H3 lysine4 trimethylation. In the <jats:italic>nrf2\u20101<\/jats:italic> mutant, a point mutation at ELF8<jats:sup>T404I<\/jats:sup>, exhibits impaired expression of <jats:italic>GENERAL REGULATORY FACTOR11<\/jats:italic> (<jats:italic>GRF11<\/jats:italic>) and downstream genes in the Fe\u2010uptake pathway.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p><jats:italic>In vivo<\/jats:italic> chromatin immunoprecipitation revealed that in roots, NRF2\/ELF8 is essential for the expression of <jats:italic>GRF11<\/jats:italic> for Fe\u2010deficiency response, whereas in shoots, NRF2\/ELF8 regulates <jats:italic>FLOWERING LOCUS C<\/jats:italic> (<jats:italic>FLC<\/jats:italic>) expression for flowering time control.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>In summary, a key factor, <jats:italic>NRF2\/ELF8<\/jats:italic>, involved in epigenetic regulation essential for both flowering time control and Fe\u2010deficiency response is uncovered.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/nph.17130","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T04:21:15Z","timestamp":1607055675000},"page":"244-258","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Histone H3 lysine4 trimethylation\u2010regulated <i>GRF11<\/i> expression is essential for the iron\u2010deficiency response in <i>Arabidopsis thaliana<\/i>"],"prefix":"10.1111","volume":"230","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9893-460X","authenticated-orcid":false,"given":"Surjit","family":"Singh","sequence":"first","affiliation":[{"name":"Agricultural Biotechnology Research Center Academia Sinica Taipei 11529 Taiwan"},{"name":"Molecular and Biological Agricultural Sciences Program Taiwan International Graduate Program Academia Sinica and National Chung Hsing University Taipei 11529 Taiwan"},{"name":"Graduate 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