{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:24:55Z","timestamp":1790803495241,"version":"4.1.0"},"reference-count":81,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,5,2]],"date-time":"2021-05-02T00:00:00Z","timestamp":1619913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["140419001"],"award-info":[{"award-number":["140419001"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["nph.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["New Phytologist"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>Global warming has reduced the productivity of many field\u2010grown crops, as the effects of high temperatures can lead to male sterility in such plants. Genetic regulation of the high temperature (HT) response in the major crop cotton is poorly understood.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>We determined the functionality and transcriptomes of the anthers of 218 cotton accessions grown under HT stress. By analyzing transcriptome divergence and implementing a genome\u2010wide association study (GWAS), we identified three thermal tolerance associated loci which contained 75 protein coding genes and 27 long noncoding RNAs, and provided expression quantitative trait loci (eQTLs) for 13\u00a0132 transcripts.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          A transcriptome\u2010wide association study (TWAS) confirmed six causal elements for the HT response (three genes overlapped with the GWAS results) which are involved in protein kinase activity. The most susceptible gene,\n                          <jats:italic>GhHRK1<\/jats:italic>\n                          , was confirmed to be a previously uncharacterized negative regulator of the HT response in both cotton and Arabidopsis.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>These functional variants provide a new understanding of the genetic basis for HT tolerance in male reproductive organs.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1111\/nph.17325","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T02:35:38Z","timestamp":1614911738000},"page":"165-181","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["A combination of genome\u2010wide and transcriptome\u2010wide association studies reveals genetic elements leading to male sterility during high temperature stress in cotton"],"prefix":"10.1111","volume":"231","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9827-5878","authenticated-orcid":false,"given":"Yizan","family":"Ma","sequence":"first","affiliation":[{"name":"National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural University Wuhan 430070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4278-0626","authenticated-orcid":false,"given":"Ling","family":"Min","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural University Wuhan 430070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1463-9708","authenticated-orcid":false,"given":"Junduo","family":"Wang","sequence":"additional","affiliation":[{"name":"Xinjiang Academy of Agricultural Science Xinjiang 830000 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