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In Arabidopsis, eggs of the butterfly species <jats:italic>Pieris brassicae<\/jats:italic> (common name large white) induce plant defenses and activate the salicylic acid (SA) pathway. We previously discovered that oviposition triggers a systemic acquired resistance (SAR) against the bacterial hemibiotroph pathogen <jats:italic>Pseudomonas syringae<\/jats:italic>.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Here, we show that insect eggs or treatment with egg extract (EE) induce SAR against the fungal necrotroph <jats:italic>Botrytis cinerea<\/jats:italic> BMM and the oomycete pathogen <jats:italic>Hyaloperonospora arabidopsidis<\/jats:italic> Noco2. This response is abolished in <jats:italic>ics1<\/jats:italic>, <jats:italic>ald1<\/jats:italic> and <jats:italic>fmo1<\/jats:italic>, indicating that the SA pathway and the N\u2010hydroxypipecolic acid (NHP) pathway are involved.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Establishment of EE\u2010induced SAR in distal leaves potentially involves tryptophan\u2010derived metabolites, including camalexin. Indeed, SAR is abolished in the biosynthesis mutants <jats:italic>cyp79B2 cyp79B3<\/jats:italic>, <jats:italic>cyp71a12 cyp71a13<\/jats:italic> and <jats:italic>pad3\u20101,<\/jats:italic> and camalexin is toxic to <jats:italic>B.\u2009cinerea in\u2009vitro<\/jats:italic>.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>This study reveals an interesting mechanism by which lepidopteran eggs interfere with plant\u2013pathogen interactions.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/nph.17732","type":"journal-article","created":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T18:29:56Z","timestamp":1631471396000},"page":"2491-2505","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Insect eggs trigger systemic acquired resistance against a fungal and an oomycete 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