{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:04:39Z","timestamp":1787162679171,"version":"build-2736575974"},"reference-count":99,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T00:00:00Z","timestamp":1655769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["nph.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["New Phytologist"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>Robust plant immunity negatively affects other fitness traits, including growth and seed production. Jasmonate (JA) confers broad\u2010spectrum protection against plant consumers by stimulating the degradation of JASMONATE ZIM\u2010DOMAIN (JAZ) proteins, which in turn relieves repression on transcription factors (TFs) coincident with reduced growth and fecundity. The molecular mechanisms underlying JA\u2010mediated decreases in fitness remain largely unknown.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          To assess the contribution of MYC TFs to growth and reproductive fitness at high levels of defence, we mutated three\n                          <jats:italic>MYC<\/jats:italic>\n                          genes in a JAZ\u2010deficient mutant (\n                          <jats:italic>jazD<\/jats:italic>\n                          ) of\n                          <jats:italic>Arabidopsis thaliana<\/jats:italic>\n                          that exhibits strong defence and low seed yield.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          Genetic epistasis analysis showed that de\u2010repression of MYC TFs in\n                          <jats:italic>jazD<\/jats:italic>\n                          not only conferred strong resistance to insect herbivory but also reduced shoot and root growth, fruit size and seed yield. We also provided evidence that the JAZ\u2013MYC module coordinates the supply of tryptophan with the production of indole glucosinolates and the proliferation of endoplasmic reticulum bodies that metabolise glucosinolates through the action of \u03b2\u2010glucosidases.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Our results establish MYCs as major regulators of growth\u2010 and reproductive\u2013defence trade\u2010offs and further indicate that these factors coordinate tryptophan availability with the production of amino acid\u2010derived defence compounds.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  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