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OXI1 regulates genes involved in reactive oxygen species (ROS) generation such as <jats:italic>RbohD<\/jats:italic> and <jats:italic>RbohF<\/jats:italic>. <jats:italic>OXI1<\/jats:italic> knock out plants show enhanced expression of nuclear and chloroplast genes of photosynthesis and enhanced growth under ambient conditions, while <jats:italic>OXI1<\/jats:italic> overexpressing plants accumulate NHP, SA, camalexin, and ROS and show a gain\u2010of\u2010function (GOF) cell death phenotype and enhanced pathogen resistance. The <jats:italic>OXI1<\/jats:italic> GOF phenotypes are\u00a0completely suppressed when compromising N\u2010hydroxypipecolic acid (NHP) synthesis in the <jats:italic>fmo1<\/jats:italic> or <jats:italic>ald1<\/jats:italic> background, showing that <jats:italic>OXI1<\/jats:italic> regulation of immunity is mediated via the NHP pathway.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Overall, these results show that OXI1 plays a key role in basal and effector\u2010triggered plant immunity by regulating defense and programmed cell death via biosynthesis of salicylic acid, N\u2010hydroxypipecolic acid, and camalexin.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/nph.18592","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T03:59:55Z","timestamp":1667361595000},"page":"1285-1301","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["OXIDATIVE 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