{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:39:42Z","timestamp":1791488382142,"version":"4.3.4"},"reference-count":95,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T00:00:00Z","timestamp":1713484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["nph.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["New Phytologist"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Leaf senescence is a complex process strictly regulated by various external and endogenous factors. However, the key signaling pathway mediating leaf senescence remains unknown.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Here, we show that Arabidopsis SPX1\/2 negatively regulate leaf senescence genetically downstream of the strigolactone (SL) pathway. We demonstrate that the SL receptor AtD14 and MAX2 mediate the age\u2010dependent degradation of SPX1\/2.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Intriguingly, we uncover an age\u2010dependent accumulation of SLs in leaves via transcriptional activation of SL biosynthetic genes by the transcription factors (TFs) SPL9\/15. Furthermore, we reveal that SPX1\/2 interact with the WRKY75 subclade TFs to inhibit their DNA\u2010binding ability and thus repress transcriptional activation of salicylic acid (SA) biosynthetic gene <jats:italic>SA Induction\u2010Deficient 2<\/jats:italic>, gating the age\u2010dependent SA accumulation in leaves at the leaf senescence onset stage.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Collectively, our new findings reveal a signaling pathway mediating sequential activation of SL and salicylate biosynthesis for the onset of leaf senescence in Arabidopsis.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1111\/nph.19760","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T23:23:15Z","timestamp":1713568995000},"page":"2524-2540","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Sequential activation of strigolactone and salicylate biosynthesis promotes 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