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This study was undertaken to elucidate the roles of three <jats:italic>IRE1<\/jats:italic> isoforms, the <jats:italic>bZIP60U<\/jats:italic> and <jats:italic>bZIP60S<\/jats:italic>, and <jats:italic>BI\u20101<\/jats:italic> roles in genetic reprogramming of cells during potexvirus infection.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Experiments were performed using <jats:italic>Arabidopsis thaliana<\/jats:italic> knockout lines and <jats:italic>Plantago asiatica mosaic virus<\/jats:italic> infectious clone tagged with the green fluorescent protein gene (PlAMV\u2010GFP).<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>There were more PlAMV\u2010GFP infection foci in <jats:italic>ire1a\/b<\/jats:italic>, <jats:italic>ire1c<\/jats:italic>, <jats:italic>bzip60<\/jats:italic>, and <jats:italic>bi\u20101<\/jats:italic> knockout than wild\u2010type (WT) plants. Cell\u2010to\u2010cell movement and systemic RNA levels were greater <jats:italic>bzip60<\/jats:italic> and <jats:italic>bi\u20101<\/jats:italic> than in WT plants. Overall, these data indicate an increased susceptibility to virus infection. Transgenic overexpression of <jats:italic>AtIRE1b<\/jats:italic> or <jats:italic>StbZIP60<\/jats:italic> in <jats:italic>ire1a\/b<\/jats:italic> or <jats:italic>bzip60<\/jats:italic> mutant background reduced virus infection foci, while <jats:italic>StbZIP60<\/jats:italic> expression influences virus movement. Transgenic overexpression of <jats:italic>StbZIP60<\/jats:italic> also confers endoplasmic reticulum (ER) stress resistance following tunicamycin treatment. We also show bZIP60U and TGB3 interact at the ER.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>This is the first demonstration of a potato <jats:italic>bZIP<\/jats:italic> transcription factor complementing genetic defects in Arabidopsis. Evidence indicates that the three IRE1 isoforms regulate the initial stages of virus replication and gene expression, while bZIP60 and BI\u20101 contribute separately to virus cell\u2010to\u2010cell and systemic movement.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/nph.19882","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T05:25:14Z","timestamp":1717997114000},"page":"1172-1189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<scp>bZIP60<\/scp> and Bax inhibitor 1 contribute <scp>IRE1<\/scp>\u2010dependent and independent roles to potexvirus infection"],"prefix":"10.1111","volume":"243","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0922-5721","authenticated-orcid":false,"given":"Binita","family":"Adhikari","sequence":"first","affiliation":[{"name":"Department of Plant Pathology and Microbiology Texas A&amp;M University  496 Olsen Blvd College 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