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However, the importance of nitric oxide (NO) produced by plants for the associated microbiota remains elusive.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Using <jats:italic>Arabidopsis thaliana<\/jats:italic> isogenic mutants overproducing NO (<jats:italic>nox1<\/jats:italic>, NO overexpression) or down\u2010producing NO (i.e. <jats:italic>nia1nia2<\/jats:italic> impaired in the expression of both nitrate reductases <jats:italic>NR1\/NIA1<\/jats:italic> and <jats:italic>NR2\/NIA2<\/jats:italic>; the <jats:italic>35s::GSNOR1<\/jats:italic> line overexpressing nitrosoglutathione reductase (GSNOR) and <jats:italic>35s::AHB1<\/jats:italic> line overexpressing haemoglobin 1 (AHB1)), we investigated how altered NO homeostasis affects microbial communities in the rhizosphere and in the roots, soil microbial activity and soil metabolites.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>We show that the rhizosphere microbiome was affected by the mutant genotypes, with the <jats:italic>nox1<\/jats:italic> and <jats:italic>nia1nia2<\/jats:italic> mutants causing opposite shifts in bacterial and fungal communities compared with the wild\u2010type (WT) Col\u20100 in the rhizosphere and roots, respectively. These mutants also exhibited distinctive soil metabolite profiles than those from the other genotypes while soil microbial activity did not differ between the mutants and the WT Col\u20100.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Our findings support our hypothesis that changes in NO production by plants can influence the plant microbiome composition with differential effects between fungal and bacterial communities.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/nph.20159","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T12:06:53Z","timestamp":1727438813000},"page":"2008-2023","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Microbiota responses to mutations affecting <scp>NO<\/scp> homeostasis in <i>Arabidopsis thaliana<\/i>"],"prefix":"10.1111","volume":"244","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0364-6654","authenticated-orcid":false,"given":"Antoine","family":"Berger","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Bourgogne, INRAE, Institut Agro Dijon, Agro\u00e9cologie  21000 Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0119-7696","authenticated-orcid":false,"given":"Eduardo","family":"P\u00e9rez\u2010Valera","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Bourgogne, INRAE, Institut Agro Dijon, Agro\u00e9cologie  21000 Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3928-9070","authenticated-orcid":false,"given":"Manuel","family":"Blouin","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Bourgogne, INRAE, Institut Agro Dijon, Agro\u00e9cologie  21000 Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Christine","family":"Breuil","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Bourgogne, INRAE, Institut Agro Dijon, Agro\u00e9cologie  21000 Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9499-6598","authenticated-orcid":false,"given":"Klaus","family":"Butterbach\u2010Bahl","sequence":"additional","affiliation":[{"name":"Institute of Meteorology and Climate Research, Atmospheric Environmental Research (IMK\u2010IFU), Karlsruhe Institute of Technology  82467 Garmisch\u2010Partenkirchen Germany"},{"name":"Land\u2010CRAFT, Department of Agroecology University of Aarhus  8000 Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Dannenmann","sequence":"additional","affiliation":[{"name":"Institute of Meteorology and Climate Research, Atmospheric Environmental Research (IMK\u2010IFU), Karlsruhe Institute of Technology  82467 Garmisch\u2010Partenkirchen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4832-738X","authenticated-orcid":false,"given":"Ang\u00e9lique","family":"Besson\u2010Bard","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Bourgogne, INRAE, Institut Agro Dijon, Agro\u00e9cologie  21000 Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6924-3586","authenticated-orcid":false,"given":"Sylvain","family":"Jeandroz","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Bourgogne, INRAE, Institut Agro Dijon, Agro\u00e9cologie  21000 Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Valls","sequence":"additional","affiliation":[{"name":"Univ. 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