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The influence of m\n                          <jats:sup>6<\/jats:sup>\n                          A has yet to be assessed under drought, one of the most impactful abiotic stresses.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          We show that\n                          <jats:italic>Arabidopsis thaliana<\/jats:italic>\n                          (L.) Heynh. (Arabidopsis) plants lacking mRNA ADENOSINE METHYLASE (MTA) are drought\u2010sensitive. Subsequently, we comprehensively assess the impacts of MTA\u2010dependent m\n                          <jats:sup>6<\/jats:sup>\n                          A changes during drought on mRNA abundance, stability, and translation in Arabidopsis.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          During drought, there is a global trend toward hypermethylation of many protein\u2010coding transcripts that does not occur in\n                          <jats:italic>mta<\/jats:italic>\n                          . We also observe complex regulation of m\n                          <jats:sup>6<\/jats:sup>\n                          A at a transcript\u2010specific level, possibly reflecting compensation by other m\n                          <jats:sup>6<\/jats:sup>\n                          A components. Importantly, a subset of transcripts that are hypermethylated in an MTA\u2010dependent manner exhibited reduced turnover and translation in\n                          <jats:italic>mta<\/jats:italic>\n                          , compared with wild\u2010type (WT) plants, during drought. Additionally, MTA impacts transcript stability and translation independently of m\n                          <jats:sup>6<\/jats:sup>\n                          A. We also correlate drought\u2010associated deposition of m\n                          <jats:sup>6<\/jats:sup>\n                          A with increased translation of modulators of drought response, such as\n                          <jats:italic>RD29A<\/jats:italic>\n                          ,\n                          <jats:italic>COR47<\/jats:italic>\n                          ,\n                          <jats:italic>COR413<\/jats:italic>\n                          ,\n                          <jats:italic>ALDH2B<\/jats:italic>\n                          ,\n                          <jats:italic>ERD7<\/jats:italic>\n                          , and\n                          <jats:italic>ABF4<\/jats:italic>\n                          in WT, which is impaired in\n                          <jats:italic>mta<\/jats:italic>\n                          .\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          m\n                          <jats:sup>6<\/jats:sup>\n                          A is dynamic during drought and, alongside MTA, promotes tolerance by regulating drought\u2010responsive changes in transcript turnover and translation.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1111\/nph.20227","type":"journal-article","created":{"date-parts":[[2024,10,27]],"date-time":"2024-10-27T23:44:22Z","timestamp":1730072662000},"page":"183-199","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["<scp>mRNA ADENOSINE METHYLASE<\/scp>\n                    promotes drought tolerance through\n                    <scp>\n                      N\n                      <sup>6<\/sup>\n                    <\/scp>\n                    \u2010methyladenosine\u2010dependent and independent impacts on\n                    <scp>mRNA<\/scp>\n                    regulation in Arabidopsis"],"prefix":"10.1111","volume":"245","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6746-0181","authenticated-orcid":false,"given":"Diep R.","family":"Ganguly","sequence":"first","affiliation":[{"name":"Department of Biology University of Pennsylvania  Philadelphia PA 19104 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Oklahoma State University  Stillwater OK 74078 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9227-6466","authenticated-orcid":false,"given":"Susheel Sagar","family":"Bhat","sequence":"additional","affiliation":[{"name":"Department of Biology University of Pennsylvania  Philadelphia PA 19104 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalini","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Oklahoma State University  Stillwater OK 74078 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei Jia","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Oklahoma State University  Stillwater OK 74078 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7532-0138","authenticated-orcid":false,"given":"Brian D.","family":"Gregory","sequence":"additional","affiliation":[{"name":"Department of Biology University of Pennsylvania  Philadelphia PA 19104 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2012-1526","authenticated-orcid":false,"given":"Ramanjulu","family":"Sunkar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Oklahoma State University  Stillwater OK 74078 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.10.020"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.17.00833"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.19.01156"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/07352680590910410"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/ery157"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2003733117"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","unstructured":"BhatSS BielewiczD KindgrenP.2023.MTA influences RNA polymerase II transcription dynamics and regulates the cold response in Arabidopsis.bioRxiv. 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