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To counteract\n                          <jats:italic>M. oryzae<\/jats:italic>\n                          , plants synthesize jasmonate (JA) and lignin, two primary defense\u2010related metabolites, to initiate defense programs. However, the mechanism through which\n                          <jats:italic>M. oryzae<\/jats:italic>\n                          modulates JA\u2010 and lignin\u2010mediated plant immunity remains unclear.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          In this study, a novel\n                          <jats:italic>M. oryzae<\/jats:italic>\n                          effector, MoBys1, was identified as being involved in pathogenesis. Knockout of\n                          <jats:italic>MoBys1<\/jats:italic>\n                          in\n                          <jats:italic>M. oryzae<\/jats:italic>\n                          significantly reduced its infection ability. Conversely, overexpression of\n                          <jats:italic>MoBys1<\/jats:italic>\n                          in rice impaired the rice defense response. MoBys1 localizes to the plant cytoplasm and nucleus and interacts with rice cinnamyl alcohol dehydrogenase 2 (OsCAD2), an enzyme that catalyzes lignin biosynthesis. While\n                          <jats:italic>OsCAD2<\/jats:italic>\n                          mutants exhibited weakened defenses, overexpression lines demonstrated enhanced resistance, highlighting the critical role of OsCAD2 in blast resistance.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Furthermore, OsCAD2 functions as a transcription factor regulating a wide range of biological processes, including JA and lignin signaling pathways. The interaction between MoBys1 and OsCAD2 promotes OsCAD2 degradation, leading to reduced lignin and JA accumulation.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          These findings uncover a novel counter\u2010defense mechanism by which\n                          <jats:italic>M. oryzae<\/jats:italic>\n                          employs the effector MoBys1 to degrade OsCAD2 and suppress host defense\u2010related metabolite accumulation during infection.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1111\/nph.20440","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T08:04:31Z","timestamp":1739433871000},"page":"280-297","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The\n                    <i>Magnaporthe oryzae<\/i>\n                    effector\n                    <scp>MoBys1<\/scp>\n                    suppresses rice immunity by targeting\n                    <scp>OsCAD2<\/scp>\n                    to manipulate host jasmonate and lignin metabolism"],"prefix":"10.1111","volume":"246","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9060-9562","authenticated-orcid":false,"given":"Chengyu","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Agricultural and Forestry Biosecurity, Key Laboratory of Ministry of Education for Genetics, Breeding and Multiple Utilization of Crops, Plant Immunity Center Fujian Agriculture and Forestry University  Fuzhou Fujian 350002 China"},{"name":"School of Future Technology Fujian Agriculture and Forestry University  Fuzhou Fujian 350002 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