{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:05:50Z","timestamp":1787061950079,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018598","name":"Japan Advanced Plant Science Network","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018598","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["nph.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["New Phytologist"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>Eclepins are root\u2010secreted compounds that induce the hatching of cyst nematodes. Solanoeclepin A (SEA) and B (SEB) have been isolated as potent hatching factors for potato cyst nematodes (PCNs). SEB is biosynthesized in roots, released into the rhizosphere, and converted into SEA by soil microorganisms. However, given that SEB and SEA exhibit comparable hatching\u2010inducing activity toward PCNs, the ecological significance of microbial solanoeclepin metabolism in eclepin\u2010mediated communication remains unclear.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>In this study, we identified solanoeclepin C (SEC), a previously unrecognized solanoeclepin secreted by tomato and potato roots. Structural analysis revealed that SEC is an acetylated derivative of SEB. Soil incubation experiments demonstrated that SEC is converted into SEB and subsequently into SEA. SEC exhibits \u200910\u2009000\u2010fold lower hatching\u2010inducing activity than SEA.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Gene expression analysis in hydroponically grown tomatoes showed that solanoeclepin biosynthesis is upregulated under nitrogen and phosphorus deficiencies, with nitrogen starvation having the strongest effect.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Our results demonstrate that although SEC itself exhibits low hatching\u2010inducing activity, it is converted by soil microorganisms into SEB and SEA, which are then exploited by PCNs to trigger their hatching. These findings reveal a previously unrecognized three\u2010way interaction among plants, soil microbes, and nematodes mediated by solanoeclepins.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1111\/nph.70252","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T03:46:13Z","timestamp":1748231173000},"page":"1370-1381","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Solanoeclepin C, a root\u2010secreted molecule converted by rhizosphere microbes to hatching factors for potato cyst nematodes"],"prefix":"10.1111","volume":"247","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2116-4226","authenticated-orcid":false,"given":"Ryota","family":"Akiyama","sequence":"first","affiliation":[{"name":"Graduate School of Agricultural Science Kobe University  Rokkodai 1\u20101, Nada Kobe Hyogo 657\u20108501 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