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We demonstrate that p22 inhibited the\u00a0nuclear localization of SlWRKY81. Furthermore, p22 entered the nucleus and impaired\u00a0the DNA binding activity of SlWRKY81, simultaneously accelerating its degradation through the ubiquitin\u201026S proteasome pathway via an unknown mechanism.<\/jats:p><\/jats:list-item>\nOur findings uncover the positive role of SlWRKY81 in regulating ABA biosynthesis in tomato and reveal mechanisms by which a viral pathogenicity factor interferes with ABA\u2010mediated antiviral defenses.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1111\/nph.70267","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T02:23:25Z","timestamp":1750645405000},"page":"1837-1854","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pathogenicity factor p22 of tomato chlorosis virus interferes with abscisic acid\u2010mediated antiviral defenses by disrupting the function of WRKY81<\/scp> in 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