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Recently, several studies have reported ferroptosis\u2010like processes in plants. However, the key genes regulating ferroptosis in plants are largely unknown. Our previous research revealed that mutations in Golgi \u03b11,2\u2010mannosidase (MNS1 and MNS2) render\n                          <jats:italic>Arabidopsis<\/jats:italic>\n                          hypersensitive to salt stress.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Trypan blue and Perls\/Perls\u2010DAB staining assessed cell death and iron accumulation, respectively. Lipid ROS accumulation was measured with C11\u2010BODIPY 581\/591, and mitochondrial ultrastructure was examined by transmission electron microscope.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          We found that\n                          <jats:italic>mns1 mns2<\/jats:italic>\n                          seedlings underwent ferroptosis in the swollen regions of the root tips under salt stress (NaCl), characterized by the accumulation of iron and lipid ROS, and the presence of ferroptosis\u2010like mitochondrial morphology. Notably, wild\u2010type seedlings exhibited an adaptive response to salt stress by depleting iron from root tips. Ferroptosis was observed in the cortex, endodermis and epidermis of the root tips in\n                          <jats:italic>mns1 mns2<\/jats:italic>\n                          and could be inhibited by iron deprivation, ciclopirox olamine or vitamin E treatment.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>We uncover a scenario in which N\u2010glycosylation defects exacerbated ferroptosis in root tips under salt stress, suggesting that ferroptosis involves secretory glycoproteins related to iron, lipid and ROS homeostasis.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  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