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Increasing Fe concentration in plants would be beneficial for agriculture and global health. The allelochemical L\u20103\u2010(3,4\u2010dihydroxyphenyl)alanine (L\u2010DOPA) can promote Fe accumulation, and its potential use for Fe biofortification was investigated.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          L\u2010DOPA was exogenously supplied to\n                          <jats:italic>Arabidopsis thaliana<\/jats:italic>\n                          , and the expression of Fe deficiency genes was measured in shoots and roots of the\n                          <jats:italic>ima8x<\/jats:italic>\n                          and\n                          <jats:italic>bhlh121<\/jats:italic>\n                          mutants defective in Fe deficiency response. L\u2010DOPA and Fe were quantified, and Fe was imaged in leaves.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          L\u2010DOPA triggers a transient and intense increase in the expression of Fe deficiency genes, leading to Fe accumulation in shoots. The transcription of Fe deficiency genes was also induced in shoots, indicating that L\u2010DOPA affected Fe perception by leaves. Surprisingly, while L\u2010DOPA accumulated in roots, it remained undetectable in shoots. The increased expression of the upstream Fe deficiency genes upon L\u2010DOPA exposure did not require functional\n                          <jats:italic>URI\/bHLH121<\/jats:italic>\n                          nor\n                          <jats:italic>IMA<\/jats:italic>\n                          genes and also occurred in rice.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>L\u2010DOPA stimulated the transcriptional response to Fe deficiency through a mechanism independent of the well\u2010known network of BASIC HELIX\u2013LOOP\u2013HELIX transcription factors that regulate Fe homeostasis. This process involved a root\u2010borne signal that activated the shoot response to Fe deficiency in Fe\u2010overloaded plants.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1111\/nph.70823","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T05:36:12Z","timestamp":1766036172000},"page":"2402-2420","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["L\u2010\n                    <scp>DOPA<\/scp>\n                    elicits iron deficiency response through root\u2010to\u2010shoot signaling and independently of the canonical regulatory pathway"],"prefix":"10.1111","volume":"249","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0401-4875","authenticated-orcid":false,"given":"En\u2010Jung","family":"Hsieh","sequence":"first","affiliation":[{"name":"Department of Agricultural Chemistry College of 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