{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:56:19Z","timestamp":1792108579279,"version":"4.4.0"},"reference-count":66,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32072559"],"award-info":[{"award-number":["32072559"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32573015"],"award-info":[{"award-number":["32573015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32360743"],"award-info":[{"award-number":["32360743"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["nph.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["New Phytologist"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>\n                          Nitric oxide (NO) and hydrogen sulphide (H\n                          <jats:sub>2<\/jats:sub>\n                          S) perform multiple regulatory functions in plants; however, the molecular mechanisms underlying NO and H\n                          <jats:sub>2<\/jats:sub>\n                          S interaction remain poorly understood. In this study, we aim to analyse the function of\n                          <jats:italic>S<\/jats:italic>\n                          \u2010nitrosoglutathione reductase (GSNOR) and L\u2010cysteine desulfhydrase (LCD) in the programmed cell death (PCD) response to cadmium (Cd\n                          <jats:sup>2+<\/jats:sup>\n                          ) stress using GSNOR and LCD knockout and overexpressing transgenic tomato (\n                          <jats:italic>Solanum lycopersicum<\/jats:italic>\n                          ). Our results confirmed that GSNOR, an enzyme that mediates NO dynamic equilibrium, and LCD, an enzyme involved in H\n                          <jats:sub>2<\/jats:sub>\n                          S generation, inhibit Cd\n                          <jats:sup>2+<\/jats:sup>\n                          stress\u2010induced PCD in tomato plants.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          GSNOR and LCD knockout plants were sensitive to Cd\n                          <jats:sup>2+<\/jats:sup>\n                          and exhibited increased cell death compared to the controls.\n                          <jats:italic>S<\/jats:italic>\n                          \u2010nitrosylation of GSNOR at Cys47 and LCD at Cys225 changed their subcellular localisation and decreased GSNOR and LCD activity, thereby increasing Cd\n                          <jats:sup>2+<\/jats:sup>\n                          uptake and promoting PCD.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          Thus,\n                          <jats:italic>S<\/jats:italic>\n                          \u2010nitrosylation attenuates the interaction between GSNOR and LCD during PCD.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          In conclusion, GSNOR and LCD are involved in the response to Cd\n                          <jats:sup>2+<\/jats:sup>\n                          stress, and their interactions and\n                          <jats:italic>S<\/jats:italic>\n                          \u2010nitrosylation play critical roles in NO\u2010 and H\n                          <jats:sub>2<\/jats:sub>\n                          S\u2010induced Cd\n                          <jats:sup>2+<\/jats:sup>\n                          stress responses.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1111\/nph.70941","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T05:42:40Z","timestamp":1769751760000},"page":"298-314","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<i>S<\/i>\n                    \u2010nitrosylation of\n                    <scp>GSNOR<\/scp>\n                    and\n                    <scp>LCD<\/scp>\n                    facilitates cadmium\u2010induced programmed cell death in tomato seedlings"],"prefix":"10.1111","volume":"250","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7717-0533","authenticated-orcid":false,"given":"Dengjing","family":"Huang","sequence":"first","affiliation":[{"name":"College of Horticulture Gansu Agricultural University  Lanzhou 730070 China"},{"name":"College of Agronomy Gansu Agricultural University  Lanzhou 730070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinfang","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Horticulture Gansu Agricultural University  Lanzhou 730070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahong","family":"Yun","sequence":"additional","affiliation":[{"name":"Pratacultural College Gansu Agricultural University  Lanzhou 730070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Fang","sequence":"additional","affiliation":[{"name":"College of Horticulture Gansu Agricultural University  Lanzhou 730070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuetong","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Horticulture Gansu Agricultural University  Lanzhou 730070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlei","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Horticulture Gansu Agricultural University  Lanzhou 730070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqiang","family":"Huo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands\/Shapotou Desert Research and Experiment Station, Northwest Institute of Eco\u2010Environment and Resources Chinese Academy of Sciences  Lanzhou 730000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7404-2145","authenticated-orcid":false,"given":"Weibiao","family":"Liao","sequence":"additional","affiliation":[{"name":"College of Horticulture Gansu Agricultural University  Lanzhou 730070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,29]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"17859","article-title":"Cadmium stress in rice plants: the effect of cadmium on seed germination and seedling growth of rice plant (Oryza sativa L.)","volume":"9","author":"Abedi E","year":"2021","journal-title":"Journal of Science and 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