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We investigated how two rhizobacteria,\n                          <jats:italic>Bradyrhizobium japonicum<\/jats:italic>\n                          and\n                          <jats:italic>Delftia acidovorans<\/jats:italic>\n                          , together with bean pod mottle virus (BPMV), shape soybean metabolism and interactions with the BPMV vector\n                          <jats:italic>Epilachna varivestis<\/jats:italic>\n                          .\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          Using a multifactorial experimental design, we combined metabolomics, transcriptomics, and pathway analyses with behavioral assays to assess the impacts of rhizobacteria inoculation and BPMV infection on soybean physiology and\n                          <jats:italic>E. varivestis<\/jats:italic>\n                          feeding preferences.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Beetle adults preferred feeding on rhizobia\u2010inoculated and virus\u2010infected plants, and larvae gained more weight on these hosts. Rhizobacteria inoculation and BPMV infection both increased primary metabolites (e.g. beta\u2010alanine, myo\u2010inositol, amino acids, and organic acids) while reducing secondary metabolites (e.g. kaempferol, rutin, and other flavonoids). Transcriptome analyses revealed shifts in defense\u2010 and metabolism\u2010related pathways, particularly under combined treatments.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Our findings demonstrate that mutualistic and pathogenic symbionts reshape soybean metabolism in unique ways when they cocolonize the same host. These changes can alter symbiont fitness, as well as vector feeding behavior and performance in ways that enhance pathogen transmission.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1111\/nph.71104","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T13:36:44Z","timestamp":1774359404000},"page":"2599-2618","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Beneficial rhizobacteria and virus infection modulate the soybean metabolome and influence the feeding preferences of the virus vector\n                    <i>Epilachna varivestis<\/i>"],"prefix":"10.1111","volume":"250","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2534-9041","authenticated-orcid":false,"given":"Hannier","family":"Pulido","sequence":"first","affiliation":[{"name":"Department of Environmental Systems Science Swiss Federal 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