{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:07:34Z","timestamp":1791562054097,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TRR175"],"award-info":[{"award-number":["TRR175"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["C01"],"award-info":[{"award-number":["C01"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["C05"],"award-info":[{"award-number":["C05"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["nph.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["New Phytologist"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Plastid\u2010to\u2010nucleus retrograde signaling coordinates nuclear gene expression with the developmental and physiological state of plastids.\n                    <jats:italic>GENOMES UNCOUPLED 1<\/jats:italic>\n                    (GUN1), a chloroplast\u2010localized PPR\u2010SMR protein, remains a central yet poorly understood component of this network. Its low abundance, rapid turnover and conditional phenotypes challenge functional interpretation. GUN1 has been proposed as a hub integrating stress responses, tetrapyrrole synthesis and protein homeostasis, with downstream effects mediated by factors, such as ABI4, but many of these claims are challenged by recent evidence. Here, we identify claims that have failed to replicate, highlight established consensus and outline a path toward a more grounded understanding of GUN1. Beyond its confirmed RNA\u2010binding activity, GUN1 may act as a moonlighting checkpoint, modulating when plastid dysfunction triggers nuclear and developmental responses.\n                  <\/jats:p>","DOI":"10.1111\/nph.71267","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T06:12:41Z","timestamp":1778739161000},"page":"81-88","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Decoding\n                    <scp>GUN1<\/scp>\n                    in plastid\u2010to\u2010nucleus signaling: what it doesn't, what it does, and why it matters"],"prefix":"10.1111","volume":"251","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1118-0738","authenticated-orcid":false,"given":"Marco","family":"Wendler","sequence":"first","affiliation":[{"name":"Plant Molecular Biology, Faculty of Biology Ludwig\u2010Maximilians\u2010Universit\u00e4t M\u00fcnchen  D\u201082152 Planegg\u2010Martinsried Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1897-8421","authenticated-orcid":false,"given":"Dario","family":"Leister","sequence":"additional","affiliation":[{"name":"Plant Molecular Biology, Faculty of Biology Ludwig\u2010Maximilians\u2010Universit\u00e4t M\u00fcnchen  D\u201082152 Planegg\u2010Martinsried Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6455-3470","authenticated-orcid":false,"given":"Tatjana","family":"Kleine","sequence":"additional","affiliation":[{"name":"Plant Molecular Biology, Faculty of Biology Ludwig\u2010Maximilians\u2010Universit\u00e4t M\u00fcnchen  D\u201082152 Planegg\u2010Martinsried Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-arplant-050213-040159"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/erq186"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","unstructured":"CuiC SunS ZhangS ZhangY KimC.2023.GENOMES UNCOUPLED1: an RNA\u2010binding protein required for early PSII biogenesis.bioRxivdoi:10.1101\/2023.09.21.558905.","DOI":"10.1101\/2023.09.21.558905"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/nph.18115"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/nph.18318"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jipb.13779"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00709-020-01578-x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/plcell\/koae105"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.18.01047"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1140516"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2022.1058831"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/tpj.15106"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/nph.20056"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/erac344"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/plcell\/koae094"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/plcell\/koac153"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/tpj.14342"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176173"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.16.01930"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jipb.70127"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-61831-w"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbi.2025.102799"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xplc.2022.100511"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8137.2008.02729.x"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1911251116"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.18.00982"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01204"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plantsci.2024.112053"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1486"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90459-4"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9102307"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/tpj.14585"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.15.02033"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xplc.2024.101069"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111364"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/plcell\/koae104"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.18.00009"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41477-019-0415-y"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/plcell\/koad290"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201900361"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.18.00772"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1820426116"}],"container-title":["New Phytologist"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/nph.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nph.71267","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nph.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nph.71267","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nph.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nph.71267","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:35:27Z","timestamp":1780547727000},"score":1,"resource":{"primary":{"URL":"https:\/\/nph.onlinelibrary.wiley.com\/doi\/10.1111\/nph.71267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,13]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/nph.71267"],"URL":"https:\/\/doi.org\/10.1111\/nph.71267","archive":["Portico"],"relation":{},"ISSN":["0028-646X","1469-8137"],"issn-type":[{"value":"0028-646X","type":"print"},{"value":"1469-8137","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,13]]},"assertion":[{"value":"2026-01-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}