{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T08:30:24Z","timestamp":1789633824227,"version":"build-2803163510"},"reference-count":61,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["nph.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["New Phytologist"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>\n                          In Arabidopsis, loss of transcription factors Calmodulin\u2010Binding Transcription Activators 1\/2\/3 (CAMTA1\/2\/3) results in enhanced defense responses with increased salicylic acid (SA) and\n                          <jats:italic>N<\/jats:italic>\n                          \u2010hydroxy\u2010pipecolic acid (NHP) biosynthesis. This is achieved through modulating the expression of master immune transcription factors SAR Deficient 1 (SARD1) and Calmodulin\u2010Binding Protein 60\u2010like g (CBP60g). SARD4 is an NHP biosynthesis enzyme, the\n                          <jats:italic>camta2\/3 sard4<\/jats:italic>\n                          triple mutant remains dwarfed and autoimmune.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          To identify positive immune regulators of the SA and NHP pathways, a forward genetic screen was performed using the\n                          <jats:italic>camta2\/3 sard4<\/jats:italic>\n                          mutant. Here, we report on a loss\u2010of\u2010function allele of\n                          <jats:italic>Late Upregulated in Response to Hyaloperonospora parasitica 1<\/jats:italic>\n                          (\n                          <jats:italic>lurp1<\/jats:italic>\n                          ) that suppresses the autoimmunity of\n                          <jats:italic>camta2\/3 sard4<\/jats:italic>\n                          .\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          <jats:italic>LURP1<\/jats:italic>\n                          transcripts are strongly induced by pathogens. Chromatin immunoprecipitation and expression analyses revealed that\n                          <jats:italic>LURP1<\/jats:italic>\n                          expression is directly controlled by SARD1.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          <jats:italic>LURP1<\/jats:italic>\n                          belongs to a small gene family. Knocking out\n                          <jats:italic>LURP1<\/jats:italic>\n                          and its three close homologs compromises both flg22\u2010 and nlp20\u2010induced resistance and SA accumulation, supporting their redundant roles in promoting plant defense. Interestingly, LURP1 interacts with the helper nucleotide\u2010binding leucine\u2010rich repeat receptor (hNLR) Activated Disease Resistance 1 (ADR1) family, suggestive of a model where LURP1 boosts pattern\u2010triggered immunity and SA\u2010mediated defense signaling through the ADR1s.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1111\/nph.71355","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:52:48Z","timestamp":1781765568000},"page":"2852-2866","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>LURP1<\/scp>\n                    , a\n                    <scp>SARD1<\/scp>\n                    \u2010regulated protein, coordinates with the helper\n                    <scp>NLR ADR1<\/scp>\n                    to promote plant immunity"],"prefix":"10.1111","volume":"251","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7413-4947","authenticated-orcid":false,"given":"Xueru","family":"Liu","sequence":"first","affiliation":[{"name":"Michael Smith Laboratories University of British Columbia  Vancouver BC V6T 1Z4 Canada"},{"name":"Department of Botany University of British Columbia  Vancouver BC V6T 1Z4 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1272-1297","authenticated-orcid":false,"given":"Weijie","family":"Huang","sequence":"additional","affiliation":[{"name":"Michael Smith Laboratories University of British Columbia  Vancouver BC V6T 1Z4 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1033-663X","authenticated-orcid":false,"given":"Zhengxi","family":"Gong","sequence":"additional","affiliation":[{"name":"Michael Smith Laboratories University of British Columbia  Vancouver BC V6T 1Z4 Canada"},{"name":"Department of Botany University of British Columbia  Vancouver BC V6T 1Z4 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenying","family":"Li","sequence":"additional","affiliation":[{"name":"Michael Smith Laboratories University of British Columbia  Vancouver BC V6T 1Z4 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Botany University of British Columbia  Vancouver BC V6T 1Z4 Canada"},{"name":"Laboratory of Plant Molecular Genetics and Crop Gene Editing, School of Life Sciences Linyi University  Linyi 276000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7619-2385","authenticated-orcid":false,"given":"Shucai","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Plant Molecular Genetics and Crop Gene Editing, School of Life Sciences Linyi University  Linyi 276000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3480-5478","authenticated-orcid":false,"given":"Yuelin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Botany University of British Columbia  Vancouver BC V6T 1Z4 Canada"},{"name":"The College of Life Sciences Sichuan University  Chengdu Sichuan 610064 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6354-2021","authenticated-orcid":false,"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Michael Smith Laboratories University of British Columbia  Vancouver BC V6T 1Z4 Canada"},{"name":"Department of Botany University of British Columbia  Vancouver BC V6T 1Z4 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07487-w"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nplants.2015.140"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI-09-18-0263-R"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmpp.2018.05.003"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/tpj.12620"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004491"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M200268200"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1805291115"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.105.036574"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05999"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-arplant-050213-040012"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2021.09.028"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.16.00486"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07612"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2008.02.037"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2024.12.003"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.17.00222"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbi.2019.02.006"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.02.049"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/tpj.14278"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abq3297"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abg7917"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abq8180"},{"key":"e_1_2_9_25_1","first-page":"11712","article-title":"Salicylic 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