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Native\u2010promoter reporter constructs corresponding to two annotated\n                          <jats:italic>PDI5<\/jats:italic>\n                          transcript isoforms show distinct subcellular enrichment, with one displaying an endoplasmic reticulum (ER)\u2010associated distribution and the other showing nuclear enrichment.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          Disruption of\n                          <jats:italic>PDI5<\/jats:italic>\n                          alters bulk glycoprotein staining and glycoside and trafficking\u2010associated transcriptional programs, reduces the abundance of PIN\u2010FORMED 2\u2010green fluorescent protein (PIN2\u2010GFP), alters its brefeldin A\u2010sensitive intracellular accumulation, and is associated with perturbed auxin\u2010response patterning and disorganized root meristems. In reproductive tissues, the\n                          <jats:italic>pdi5<\/jats:italic>\n                          mutant shows abnormal germline\u2010associated cell\u2010fate restriction, impaired meiotic chromosome behavior, reduced chiasma formation and decreased fertility. Proteomic and interaction analyses identify the cohesin subunit SISTER\u2010CHROMATID COHESION PROTEIN 3 (SCC3) as a PDI5\u2010associated protein, and disruption of a conserved SCC3 N809\u2010centered motif reduces its detectable association with PDI5. In a\n                          <jats:italic>PDI5<\/jats:italic>\n                          promoter\u2010driven conditional complementation assay, SCC3^N809E fails to support fertility rescue.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>These findings support a model in which PDI5\u2010dependent proteostasis contributes to auxin\u2010associated developmental patterning and meiotic chromosome fidelity, potentially through compartmentally distributed PDI5 functions.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1111\/nph.71522","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T09:21:43Z","timestamp":1787822503000},"page":"628-646","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dual localization of\n                    <scp>PDI5<\/scp>\n                    couples endoplasmic reticulum proteostasis to meristem organization and meiotic fidelity in\n                    <i>Arabidopsis<\/i>"],"prefix":"10.1111","volume":"252","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3910-1699","authenticated-orcid":false,"given":"Mohammad","family":"Aslam","sequence":"first","affiliation":[{"name":"College of Life Sciences, Fujian Provincial Key Laboratory of Haixia Plant Systems Biology, Haixia Institute of Science and Technology Fujian Agriculture and Forestry University No. 15 Shangxiadian Road, Cangshan District Fuzhou City 350002 Fujian Province China"},{"name":"Donald Danforth Plant Science Center Saint Louis 63132 MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3824-5030","authenticated-orcid":false,"given":"Beenish","family":"Fakher","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Fujian Provincial Key Laboratory of Haixia Plant Systems Biology, Haixia Institute of Science and Technology Fujian Agriculture and Forestry University No. 15 Shangxiadian Road, Cangshan District Fuzhou City 350002 Fujian Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5629-6910","authenticated-orcid":false,"given":"Bello Hassan","family":"Jakada","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Fujian Provincial Key Laboratory of Haixia Plant Systems Biology, Haixia Institute of Science and Technology Fujian Agriculture and Forestry University No. 15 Shangxiadian Road, Cangshan District Fuzhou City 350002 Fujian Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4713-6151","authenticated-orcid":false,"given":"Yuan","family":"Qin","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Fujian Provincial Key Laboratory of Haixia Plant Systems Biology, Haixia Institute of Science and Technology Fujian Agriculture and Forestry University No. 15 Shangxiadian Road, Cangshan District Fuzhou City 350002 Fujian Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6091-888X","authenticated-orcid":false,"given":"Hanyang","family":"Cai","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Fujian Provincial Key Laboratory of Haixia Plant Systems Biology, Haixia Institute of Science and Technology Fujian Agriculture and Forestry University No. 15 Shangxiadian Road, Cangshan District Fuzhou City 350002 Fujian Province 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