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While the mechanism has been well studied in photosynthetic tissues, the physiological role and regulatory mechanism of plastid signaling in nonphotosynthetic tissues remain poorly understood.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>GENOME UNCOUPLED 1 (GUN1) is a key mediator of plastid signaling in photosynthetic tissues. Here, we demonstrate that GUN1 is also involved in plastid signaling in roots when plastid translation is influenced by impaired translation elongation factor Tu activity or ribosome inhibition in Arabidopsis.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          Upon plastid translation stress, GUN1\u2010dependent signaling promotes the protein stabilization of the NAC transcription factor NAC103 specifically in the root transition zone. NAC103 conducts metabolism\u2010related regulation, ensuring\n                          <jats:italic>de novo<\/jats:italic>\n                          fatty acid biosynthesis by directly activating the gene encoding ACETYL\u2010CoA CARBOXYLASE 2 (ACC2) but repressing genes involved in tryptophan\u2010related metabolism. This coordinated gene reprogramming, particularly the activation of\n                          <jats:italic>ACC2<\/jats:italic>\n                          , is indispensable for sustaining cell viability in the transition zone. We further characterized that the GUN1\u2010NAC103\u2010ACC2 signaling is involved in root growth adaptation under iron\u2010deficient stress.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Overall, we identified a GUN1\u2010NAC103 signaling axis required for sustaining root growth under plastid translation stress, distinct from signaling responses characterized in photosynthetic tissues.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1111\/nph.71524","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:22:52Z","timestamp":1787322172000},"page":"666-684","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The\n                    <scp>GUN1<\/scp>\n                    \u2010\n                    <scp>NAC103<\/scp>\n                    axis\u2010mediated plastid signaling sustains root growth under plastid translation stress"],"prefix":"10.1111","volume":"252","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9363-4907","authenticated-orcid":false,"given":"Pengcheng","family":"Li","sequence":"first","affiliation":[{"name":"Institute of Crop Germplasm Resources (Biotechnology Research Center) Shandong Academy of Agricultural Sciences  Jinan Shandong 250100 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Crop Germplasm Resources (Biotechnology Research Center) Shandong Academy of Agricultural Sciences  Jinan Shandong 250100 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Gao","sequence":"additional","affiliation":[{"name":"College of Life Sciences Shandong Normal University  Jinan Shandong 250014 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5531-7273","authenticated-orcid":false,"given":"Xingjun","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Crop Germplasm Resources (Biotechnology Research Center) Shandong Academy of Agricultural Sciences  Jinan Shandong 250100 PR China"},{"name":"College of Life Sciences Shandong Normal University  Jinan Shandong 250014 PR 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