{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:51:51Z","timestamp":1791175911810,"version":"4.1.0"},"reference-count":78,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["nph.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["New Phytologist"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>\n                          Phytophthora root rot, caused by\n                          <jats:italic>Phytophthora sojae<\/jats:italic>\n                          , is a devastating soilborne disease of soybean (\n                          <jats:italic>Glycine max<\/jats:italic>\n                          ). However, the epigenetic regulation of soybean responses to\n                          <jats:italic>P. sojae<\/jats:italic>\n                          remains incompletely understood.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Here, using genetic, molecular and biochemical approaches, we characterized the functions of LIKE HETEROCHROMATIN PROTEIN 1 (GmLHP1) and its downstream regulatory network.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          We demonstrated that GmLHP1, as a reader of H3K27me3, negatively regulates soybean resistance to\n                          <jats:italic>P. sojae<\/jats:italic>\n                          . GmLHP1 binds to H3K27me3 peptides\n                          <jats:italic>in vitro<\/jats:italic>\n                          and colocalizes with H3K27me3 marks genome\u2010wide\n                          <jats:italic>in vivo<\/jats:italic>\n                          . The integrated chromatin immunoprecipitation sequencing and\n                          <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                          sequencing analysis identified the ethylene biosynthesis pathway gene\n                          <jats:italic>1\u2010AMINO\u2010CYCLOPROPANE\u20101\u2010CARBOXYLATE SYNTHASE 18<\/jats:italic>\n                          (\n                          <jats:italic>GmACS18<\/jats:italic>\n                          ) as being enriched for H3K27me3 and bound by GmLHP1, leading to its transcriptional downregulation. Notably, GmLHP1 associates with the\n                          <jats:italic>GmACS18<\/jats:italic>\n                          promoter by directly binding to AATTAA motifs and recognizing H3K27me3 marks. Moreover, GmACS18 enhances defense against\n                          <jats:italic>P. sojae<\/jats:italic>\n                          by accumulating the ethylene precursor 1\u2010aminocyclopropane\u20101\u2010carboxylic acid (ACC). Further analysis unveiled that recognition of H3K27me3 by GmLHP1 is essential for regulating soybean resistance to\n                          <jats:italic>P. sojae<\/jats:italic>\n                          through repressing\n                          <jats:italic>GmACS18<\/jats:italic>\n                          transcription and decreasing ACC accumulation.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          Our findings reveal a novel epigenetic regulatory mechanism in which the H3K27me3 reader GmLHP1 blocks soybean resistance to\n                          <jats:italic>P. sojae<\/jats:italic>\n                          by repressing ethylene precursor ACC accumulation.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1111\/nph.71550","type":"journal-article","created":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:45:06Z","timestamp":1788583506000},"page":"1199-1214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The\n                    <scp>H3K27me3<\/scp>\n                    reader\n                    <scp>GmLHP1<\/scp>\n                    impairs\n                    <i>Phytophthora sojae<\/i>\n                    resistance by repressing ethylene precursor accumulation in soybean"],"prefix":"10.1111","volume":"252","author":[{"given":"Xin","family":"Fang","sequence":"first","affiliation":[{"name":"Soybean Research Institute of Northeast Agricultural University\/Key Laboratory of Soybean Biology of Chinese Education Ministry  Harbin 150030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Ni","sequence":"additional","affiliation":[{"name":"Soybean 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