{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:02:54Z","timestamp":1790136174850,"version":"4.0.1"},"reference-count":79,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["nph.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["New Phytologist"],"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>\n                          Rice blast, caused by\n                          <jats:italic>Magnaporthe oryzae<\/jats:italic>\n                          , is one of the most destructive diseases threatening global rice production. Race\u2010independent broad\u2010spectrum resistance (BSR) holds the ideal strategy for durable rice blast management, yet its molecular mechanisms remain largely obscure.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          Here, we identified and characterized\n                          <jats:italic>elicitor\u2010triggered cell death 1<\/jats:italic>\n                          (\n                          <jats:italic>etd1<\/jats:italic>\n                          ), a rice lesion mimic mutant that displays spontaneous cell death and hypersensitive response (HR)\u2010like necrosis upon challenge with\n                          <jats:italic>M. oryzae<\/jats:italic>\n                          elicitors.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          Genetic analysis reveals that\n                          <jats:italic>etd1<\/jats:italic>\n                          encodes a hypermorphic haplotype of rice Cyclic Nucleotide\u2010Gated Channel 13 (OsCNGC13) protein, harboring a single glycine\u2010to\u2010glutamic acid substitution (G483E) in the highly conserved gating domain of the CNGC family. This mutation transforms OsCNGC13 into a hyperactive Ca\n                          <jats:sup>2+<\/jats:sup>\n                          \u2010permeable channel (etd1), driving ectopic Ca\n                          <jats:sup>2+<\/jats:sup>\n                          influx under both developmental and pathogenic conditions that lead to cell death. Although detrimental to agronomic traits,\n                          <jats:italic>etd1<\/jats:italic>\n                          confers robust BSR against all 108 tested\n                          <jats:italic>M. oryzae<\/jats:italic>\n                          isolates by effectively blocking fungal colonization through ectopic Ca\n                          <jats:sup>2+<\/jats:sup>\n                          influx\u2010induced cell death.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          Our data demonstrate that hyperactivation of a Ca\n                          <jats:sup>2+<\/jats:sup>\n                          \u2010permeable channel can confer rice BSR through Ca\n                          <jats:sup>2+<\/jats:sup>\n                          \u2010mediated cell death. The discovery of\n                          <jats:italic>etd1<\/jats:italic>\n                          provides a valuable clue for breeding rice with broad\u2010spectrum blast resistance based on Ca\n                          <jats:sup>2+<\/jats:sup>\n                          \u2010permeable channels.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1111\/nph.71579","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T03:16:41Z","timestamp":1790133401000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A hypermorphic allele of\n                    <i>CNGC<\/i>\n                    confers broad\u2010spectrum blast resistance through ectopic calcium influx\u2010induced cell death in rice"],"prefix":"10.1111","author":[{"given":"Jianbin","family":"Liu","sequence":"first","affiliation":[{"name":"College of Plant Protection Jilin Agricultural University  Changchun 130118 China"},{"name":"College of Agronomy Hunan Agricultural University  Changsha 410128 China"},{"name":"State Key Laboratory of Hybrid Rice, Hunan Hybrid Rice Research Center  Changsha 410128 China"},{"name":"Yuelushan Laboratory  Changsha 410128 China"},{"name":"IRRI\u2010JAAS Joint Lab, and IRRI\u2010China Japonica Rice Research Center  Nanjing 210014 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui","family":"Xiao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Hybrid Rice, Hunan Hybrid Rice Research Center  Changsha 410128 China"},{"name":"Yuelushan Laboratory  Changsha 410128 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology, Hubei Hongshan Laboratory Huazhong Agricultural University  Wuhan 430070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liang","sequence":"additional","affiliation":[{"name":"College of Agronomy Hunan Agricultural University  Changsha 410128 China"},{"name":"State Key Laboratory of Hybrid Rice, Hunan Hybrid Rice Research Center  Changsha 410128 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaofeng","family":"Yi","sequence":"additional","affiliation":[{"name":"College of Agronomy Hunan Agricultural University  Changsha 410128 China"},{"name":"State Key Laboratory of Hybrid Rice, Hunan Hybrid Rice Research Center  Changsha 410128 China"},{"name":"Yuelushan Laboratory  Changsha 410128 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Bai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Hybrid Rice, Hunan Hybrid Rice Research Center  Changsha 410128 China"},{"name":"Yuelushan Laboratory  Changsha 410128 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiushuo","family":"Liang","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology, Hubei Hongshan Laboratory Huazhong Agricultural University  Wuhan 430070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Luo","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology, Hubei Hongshan Laboratory Huazhong Agricultural University  Wuhan 430070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yuan","sequence":"additional","affiliation":[{"name":"College of Agronomy Hunan Agricultural University  Changsha 410128 China"},{"name":"Yuelushan Laboratory  Changsha 410128 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4810-0225","authenticated-orcid":false,"given":"Jie","family":"Yang","sequence":"additional","affiliation":[{"name":"IRRI\u2010JAAS Joint Lab, and IRRI\u2010China Japonica Rice Research Center  Nanjing 210014 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8838-3362","authenticated-orcid":false,"given":"Shaowu","family":"Xue","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology, Hubei Hongshan Laboratory Huazhong Agricultural University  Wuhan 430070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6352-2461","authenticated-orcid":false,"given":"Wenxian","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Plant Protection Jilin Agricultural University  Changchun 130118 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhou","sequence":"additional","affiliation":[{"name":"IRRI\u2010JAAS Joint Lab, and IRRI\u2010China Japonica Rice Research Center  Nanjing 210014 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7351-6284","authenticated-orcid":false,"given":"Jun","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Agronomy Hunan Agricultural University  Changsha 410128 China"},{"name":"State Key Laboratory of Hybrid Rice, Hunan Hybrid Rice Research Center  Changsha 410128 China"},{"name":"Yuelushan Laboratory  Changsha 410128 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1104\/pp.113.217539","article-title":"A suppressor screen of the chimeric AtCNGC11\/12 reveals residues 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