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Small RNAs (sRNAs), mediating RNA silencing, have a well\u2010established role in antiviral immunity; however, their role in HR has not been addressed to date.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          We applied a spatially resolved sRNA\u2010omics approach to uncover changes at the sRNA level and the dynamics of sRNA\u2013gene regulatory networks in potato (\n                          <jats:italic>Solanum tuberosum<\/jats:italic>\n                          L.) HR to potato virus Y (PVY).\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          We show that miR160 is repressed in cells adjacent to HR lesions in the resistant cultivar, but not in PVY\u2010sensitive, salicylic acid (SA)\u2010depleted plants. Beyond its canonical regulation of\n                          <jats:italic>StARF10<\/jats:italic>\n                          and\n                          <jats:italic>StARF17<\/jats:italic>\n                          , miR160 controls a broader regulatory network spanning auxin signaling, cell\u2010wall remodeling, redox homeostasis, and tuberization. Elevated miR160 levels promote susceptibility\u2010associated traits, reduce thermotolerance, and suppress genes strongly activated in HR.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          Mechanistically, we identify a novel miR160\u2013\n                          <jats:italic>StARF10\/StARF17<\/jats:italic>\n                          \u2013\n                          <jats:italic>StPRX28<\/jats:italic>\n                          module that links miR160 repression to the induction of a Class III apoplastic peroxidase in HR, with SA acting upstream. Together, these findings establish miR160 as an important regulatory node that connects SA\u2013auxin\u2013redox signaling pathways and tunes development, defense, and heat resilience, and highlight miR160 as a promising target for fine\u2010tuning tolerance to multiple stresses with minimal yield loss.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1111\/nph.71646","type":"journal-article","created":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T06:45:41Z","timestamp":1792305941000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>MicroRNA<\/scp>\n                    160 controls the auxin response factor\u2013class\n                    <scp>III<\/scp>\n                    peroxidase module and couples salicylic acid and redox signaling networks in the potato hypersensitive response to potato virus Y"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5710-9117","authenticated-orcid":false,"given":"Maja","family":"Kri\u017enik","sequence":"first","affiliation":[{"name":"Department of Biotechnology and Systems Biology National Institute of Biology  Ljubljana 1000 Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6235-2816","authenticated-orcid":false,"given":"Tja\u0161a","family":"Lukan","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Systems Biology National Institute of Biology  Ljubljana 1000 Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1669-6482","authenticated-orcid":false,"given":"Maja","family":"Zagor\u0161\u010dak","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Systems Biology National Institute of Biology  Ljubljana 1000 Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0672-1530","authenticated-orcid":false,"given":"Anna","family":"Coll Rius","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Systems Biology National Institute of Biology  Ljubljana 1000 Slovenia"},{"name":"Semillas Fit\u00f3  Barcelona 08019 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5190-7217","authenticated-orcid":false,"given":"Karmen","family":"Poga\u010dar","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Systems Biology National Institute of Biology  Ljubljana 1000 Slovenia"},{"name":"Jo\u017eef Stefan International Postgraduate School  Ljubljana 1000 Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nastja","family":"Marondini","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Systems Biology National Institute of Biology  Ljubljana 1000 Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3999-9400","authenticated-orcid":false,"given":"Katja","family":"Stare","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Systems Biology National Institute of Biology  Ljubljana 1000 Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5975-4032","authenticated-orcid":false,"given":"Valentina","family":"Levak","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Systems Biology National Institute of Biology  Ljubljana 1000 Slovenia"},{"name":"Jo\u017eef Stefan International Postgraduate School  Ljubljana 1000 Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4988-2919","authenticated-orcid":false,"given":"Jitka","family":"\u0160irok\u00e1","sequence":"additional","affiliation":[{"name":"Laboratory of Growth Regulators, Faculty of Science Palack\u00fd University and Institute of Experimental Botany, The Czech Academy of Sciences  Olomouc 77900 Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3452-0154","authenticated-orcid":false,"given":"Ond\u0159ej","family":"Nov\u00e1k","sequence":"additional","affiliation":[{"name":"Laboratory of Growth Regulators, Faculty of Science Palack\u00fd University and Institute of Experimental Botany, The Czech Academy of Sciences  Olomouc 77900 Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3466-0088","authenticated-orcid":false,"given":"Ale\u0161","family":"Kladnik","sequence":"additional","affiliation":[{"name":"Department of Biology, Biotechnical Faculty University of Ljubljana  Ljubljana 1000 Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5906-8569","authenticated-orcid":false,"given":"Kristina","family":"Gruden","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Systems Biology National Institute of Biology  Ljubljana 1000 Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,17]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"1","article-title":"High throughput image\u2010based phenotyping for determining morphological and physiological responses to single and combined stresses in 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