{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:46:32Z","timestamp":1791863192486,"version":"4.3.4"},"reference-count":87,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003006","name":"Eidgen\u00f6ssische Technische Hochschule Z\u00fcrich","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["nph.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["New Phytologist"],"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>\n                          Endopolyploidy (within\u2010organism polyploidy) is an often\u2010beneficial aspect of development. But polyploids, which have a higher baseline genome content, have been reported to have less endoreduplication than diploid relatives. Why has remained unclear; we explored this in\n                          <jats:italic>Arabidopsis arenosa.<\/jats:italic>\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          We measured endopolyploidy levels and phenotyped cellular traits, comparing diploids, neo\u2010autotetraploids, and established autotetraploids of\n                          <jats:italic>A. arenosa<\/jats:italic>\n                          . We used a genetic approach to ask whether\n                          <jats:italic>CYCD3;2<\/jats:italic>\n                          , a polyploidy regulator with evidence of selection in tetraploids, might be responsible for endopolyploidy\u2010related phenotypic differences between neo\u2010 and established polyploids, and whether there are associated costs.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          Neo\u2010tetraploids had the most 16C and 32C cells, whereas established tetraploids have proportions of 16C and 32C cells comparable to diploids. Tetraploid plants homozygous for a novel allele of\n                          <jats:italic>CYCD3;2<\/jats:italic>\n                          have reduced endopolyploidy compared to homozygotes for the diploid allele and, surprisingly, also show cellular defects seen in neo\u2010tetraploids. Suggesting this link is specific, we find that\n                          <jats:italic>A. thaliana cycd3;2<\/jats:italic>\n                          mutants have not only increased endopolyploidy but also root hair defects like neo\u2010tetraploids.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Our results suggest reverting endopolyploidy in polyploids to diploid\u2010like levels could be advantageous, and that one driver might be cellular defects that arise with excess high\u2010ploidy cells.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1111\/nph.71647","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:07:40Z","timestamp":1791860860000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Excess endopolyploidy associated with cellular defects in neo\u2010autotetraploid\n                    <i>Arabidopsis arenosa<\/i>\n                    is in part corrected by a naturally evolved allele of\n                    <i>CYCD3;2<\/i>"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8946-6023","authenticated-orcid":false,"given":"Anis","family":"Meschichi","sequence":"first","affiliation":[{"name":"Department of Biology, Institute of Molecular Plant Biology ETH Z\u00fcrich  Auguste\u2010Piccard\u2010Hof 1 8093 Z\u00fcrich 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Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8969-1447","authenticated-orcid":false,"given":"Tadeas J.","family":"Priklopil","sequence":"additional","affiliation":[{"name":"Department of Biology, Institute of Molecular Plant Biology ETH Z\u00fcrich  Auguste\u2010Piccard\u2010Hof 1 8093 Z\u00fcrich Switzerland"},{"name":"Department of Environmental Systems Science, Institute of Integrative Biology ETH Z\u00fcrich  Universit\u00e4tsstrasse 16 8092 Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui San","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Biology, Institute of Molecular Plant Biology ETH Z\u00fcrich  Auguste\u2010Piccard\u2010Hof 1 8093 Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2434-3863","authenticated-orcid":false,"given":"Kirsten","family":"Bomblies","sequence":"additional","affiliation":[{"name":"Department of Biology, Institute of Molecular Plant Biology ETH Z\u00fcrich  Auguste\u2010Piccard\u2010Hof 1 8093 Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1093\/molbev\/msv089","article-title":"Single geographic origin of a widespread autotetraploid Arabidopsis arenosa lineage followed by interploidy admixture","volume":"32","author":"Arnold B","year":"2015","journal-title":"Molecular Biology and Evolution"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/bies.20371","article-title":"Endopolyploidy in seed 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