{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:37:24Z","timestamp":1792730244092,"version":"4.5.0"},"reference-count":75,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32571909"],"award-info":[{"award-number":["32571909"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42350610257"],"award-info":[{"award-number":["42350610257"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42377124"],"award-info":[{"award-number":["42377124"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42477122"],"award-info":[{"award-number":["42477122"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["nph.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["New Phytologist"],"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>\n                          Microbial volatile organic compounds (mVOCs) suppress growth and virulence traits of soil\u2010borne pathogens, yet their ecological roles in disease suppression remain unclear. Here, we show that the sesquiterpene humulene from\n                          <jats:italic>Streptomyces<\/jats:italic>\n                          acts as a multifunctional regulator that suppresses bacterial wilt through coordinated inhibition of\n                          <jats:italic>Ralstonia solanacearum<\/jats:italic>\n                          , plant metabolic reprogramming, and rhizosphere microbiome modulation.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          We combined\n                          <jats:italic>in vitro<\/jats:italic>\n                          pathogen assays, pot experiments, microbiota transplantation, rhizosphere 16S rRNA profiling, root\u2010exudate metabolomics, and plant and pathogen transcriptomics to investigate the direct and microbiome\u2010mediated effects of humulene.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          Humulene reduced disease severity and pathogen abundance via a microbiome\u2010dependent mechanism. Microbiota transplantation confirmed that the humulene\u2010conditioned microbiome retains transferable disease\u2010suppressiveness. Humulene also selectively enriched antagonistic\n                          <jats:italic>Streptomyces<\/jats:italic>\n                          , not by direct growth promotion, but by reprogramming tomato root exudation to produce lipid\u2010derived petroselinic acid, which promoted\n                          <jats:italic>Streptomyces<\/jats:italic>\n                          growth, humulene production, and pathogen suppression. Root transcriptomics further revealed activation of lipid metabolic pathways involving alternative fatty acid desaturation and oxylipin signaling.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Together, humulene functions as an ecological signal that integrates pathogen suppression, host lipid metabolism, and microbiome assembly to establish a disease\u2010suppressive rhizosphere, enabling microbiome\u2010informed control of bacterial wilt.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1111\/nph.71689","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:39:12Z","timestamp":1792726752000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Microbial volatile humulene orchestrates plant\u2013microbe alliance to establish disease\u2010suppressive rhizosphere"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4119-5986","authenticated-orcid":false,"given":"Yishuo","family":"Huang","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of Organic\u2010based Fertilizer Creation and Soil Health Manipulation, National Engineering Research Center for Organic\u2010based Fertilizers, Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization Nanjing Agricultural University  Binjiang Avenue 666, Jiangbei New District Nanjing 211800 Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3784-3497","authenticated-orcid":false,"given":"Fengling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Organic\u2010based Fertilizer Creation and Soil Health Manipulation, National Engineering Research Center for Organic\u2010based Fertilizers, Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization Nanjing Agricultural University  Binjiang Avenue 666, Jiangbei New District Nanjing 211800 Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8661-8789","authenticated-orcid":false,"given":"Jinlong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Organic\u2010based Fertilizer Creation and Soil Health Manipulation, National Engineering Research Center for Organic\u2010based Fertilizers, Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization Nanjing Agricultural University  Binjiang Avenue 666, Jiangbei New District Nanjing 211800 Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2535-1398","authenticated-orcid":false,"given":"Weiqi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Organic\u2010based Fertilizer Creation and Soil Health Manipulation, National Engineering Research Center for Organic\u2010based Fertilizers, Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization Nanjing Agricultural University  Binjiang Avenue 666, Jiangbei New District Nanjing 211800 Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7788-4364","authenticated-orcid":false,"given":"Ningqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Organic\u2010based Fertilizer Creation and Soil Health Manipulation, National Engineering Research Center for Organic\u2010based Fertilizers, Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization Nanjing Agricultural University  Binjiang Avenue 666, Jiangbei New District Nanjing 211800 Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5030-1686","authenticated-orcid":false,"given":"Xiaofang","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Organic\u2010based Fertilizer Creation and Soil Health Manipulation, National Engineering Research Center for Organic\u2010based Fertilizers, Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization Nanjing Agricultural University  Binjiang Avenue 666, Jiangbei New District Nanjing 211800 Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7967-4897","authenticated-orcid":false,"given":"Zhong","family":"Wei","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Organic\u2010based Fertilizer Creation and Soil Health Manipulation, National Engineering Research Center for Organic\u2010based Fertilizers, Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization Nanjing Agricultural University  Binjiang Avenue 666, Jiangbei New District Nanjing 211800 Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5331-739X","authenticated-orcid":false,"given":"Gaofei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Organic\u2010based Fertilizer Creation and Soil Health Manipulation, National Engineering Research Center for Organic\u2010based Fertilizers, Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization Nanjing Agricultural University  Binjiang Avenue 666, Jiangbei New District Nanjing 211800 Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0429-8628","authenticated-orcid":false,"given":"Waseem","family":"Raza","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Tropical Crop Breeding, Sanya Research Institute, Institute of Tropical Bioscience and Biotechnology Chinese Academy of Tropical Agricultural Sciences  Haikou 571101 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","DOI":"10.1038\/s43247-026-03685-8","article-title":"Volatile organic compound\u2010mediated conversation in soil","volume":"7","author":"Ali Q","year":"2026","journal-title":"Communications Earth & Environment"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.tplants.2012.04.001","article-title":"The rhizosphere microbiome and plant health","volume":"17","author":"Berendsen RL","year":"2012","journal-title":"Trends in Plant Science"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1104\/pp.104.3.845","article-title":"Apparent role of phosphatidylcholine in the metabolism of petroselinic acid 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herbivores","volume":"47","author":"Li Z","year":"2024","journal-title":"Plant, Cell & Environment"},{"key":"e_1_2_9_28_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2023.117722","article-title":"Long\u2010term fertilization suppresses rice pathogens by microbial volatile compounds","volume":"336","author":"Liang Y","year":"2023","journal-title":"Journal of Environmental Management"},{"key":"e_1_2_9_29_1","doi-asserted-by":"crossref","DOI":"10.1093\/femsec\/fiaa255","article-title":"microeco: an R package for data mining in microbial community ecology","volume":"97","author":"Liu C","year":"2021","journal-title":"FEMS Microbiology Ecology"},{"key":"e_1_2_9_30_1","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1038\/s41477-024-01749-1","article-title":"Harnessing co\u2010evolutionary interactions between plants and Streptomyces to combat drought stress","volume":"10","author":"Liu H","year":"2024","journal-title":"Nature 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P","year":"2013","journal-title":"Chembiochem"},{"key":"e_1_2_9_40_1","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/s41559-023-02297-1","article-title":"Microbe\u2010induced phenotypic variation leads to overyielding in clonal plant populations","volume":"8","author":"Raza W","year":"2024","journal-title":"Nature Ecology & Evolution"},{"key":"e_1_2_9_41_1","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.scitotenv.2017.07.023","article-title":"Profiling of soil volatile organic compounds after long\u2010term application of inorganic, organic and organic\u2010inorganic mixed fertilizers and their effect on plant growth","volume":"607","author":"Raza W","year":"2017","journal-title":"Science of the Total Environment"},{"key":"e_1_2_9_42_1","doi-asserted-by":"crossref","first-page":"20200403","DOI":"10.1098\/rspb.2020.0403","article-title":"Bacterial community richness shifts the balance between volatile organic compound\u2010mediated microbe\u2010pathogen and microbe\u2010plant interactions","volume":"287","author":"Raza W","year":"2020","journal-title":"Proceedings of the Royal Society B\u2010Biological Sciences"},{"key":"e_1_2_9_43_1","doi-asserted-by":"crossref","first-page":"7639","DOI":"10.1007\/s00253-016-7584-7","article-title":"Effects of volatile organic compounds produced by Bacillus amyloliquefaciens on the growth and virulence traits of tomato bacterial wilt pathogen Ralstonia solanacearum","volume":"100","author":"Raza W","year":"2016","journal-title":"Applied Microbiology and Biotechnology"},{"key":"e_1_2_9_44_1","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.00849-21","article-title":"Extended plant metarhizobiome: Understanding volatile organic compound signaling in plant\u2010microbe metapopulation networks","volume":"6","author":"Raza 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