{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T17:44:17Z","timestamp":1791481457200,"version":"4.3.4"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutr Rev"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1111\/nure.12081","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:47:07Z","timestamp":1381542427000},"page":"822-835","source":"Crossref","is-referenced-by-count":165,"title":["Effects of resveratrol supplementation on plasma lipids: a systematic review and meta-analysis of randomized controlled trials"],"prefix":"10.1093","volume":"71","author":[{"given":"Amirhossein","family":"Sahebkar","sequence":"first","affiliation":[{"name":"Biotechnology Research Center; Mashhad University of Medical Sciences; Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,10,1]]},"reference":[{"key":"10.1111\/nure.12081-BIB0001|nure12081-cit-0001","first-page":"545","article-title":"Future cardiovascular endpoint studies: where will the research take us?","volume":"84","author":"LaRosa","year":"1999","journal-title":"Am J Cardiol"},{"key":"10.1111\/nure.12081-BIB0002|nure12081-cit-0002","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s11745-010-3408-1","article-title":"Atherogenic dyslipidemia: cardiovascular risk and dietary intervention","volume":"45","author":"Musunuru","year":"2010","journal-title":"Lipids"},{"issue":"Suppl F","key":"10.1111\/nure.12081-BIB0003|nure12081-cit-0003","doi-asserted-by":"crossref","first-page":"F40","DOI":"10.1093\/eurheartj\/sul040","article-title":"Dyslipidaemia and global cardiovascular risk: clinical issues","volume":"8","author":"Assmann","year":"2006","journal-title":"Eur Heart J Suppl"},{"key":"10.1111\/nure.12081-BIB0004|nure12081-cit-0004","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/S0140-6736(05)67394-1","article-title":"Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins","volume":"366","author":"Baigent","year":"2005","journal-title":"Lancet"},{"key":"10.1111\/nure.12081-BIB0005|nure12081-cit-0005","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/MOL.0b013e32825a6773","article-title":"The broad spectrum of statin myopathy: from myalgia to rhabdomyolysis","volume":"18","author":"Harper","year":"2007","journal-title":"Curr Opin Lipidol"},{"key":"10.1111\/nure.12081-BIB0006|nure12081-cit-0006","doi-asserted-by":"crossref","first-page":"373","DOI":"10.2165\/0129784-200808060-00004","article-title":"Statin adverse effects: a review of the literature and evidence for a mitochondrial mechanism","volume":"8","author":"Golomb","year":"2008","journal-title":"Am J Cardiovasc Drugs"},{"key":"10.1111\/nure.12081-BIB0007|nure12081-cit-0007","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.amjcard.2010.05.002","article-title":"Contribution of high plasma triglycerides and low high-density lipoprotein cholesterol to residual risk of coronary heart disease after establishment of low-density lipoprotein cholesterol control","volume":"106","author":"Carey","year":"2010","journal-title":"Am J Cardiol"},{"key":"10.1111\/nure.12081-BIB0008|nure12081-cit-0008","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.amjmed.2005.11.015","article-title":"Contemporary management of dyslipidemia in high-risk patients: targets still not met","volume":"119","author":"Yan","year":"2006","journal-title":"Am J Med"},{"key":"10.1111\/nure.12081-BIB0009|nure12081-cit-0009","doi-asserted-by":"crossref","first-page":"e19881","DOI":"10.1371\/journal.pone.0019881","article-title":"What is new for an old molecule? Systematic review and recommendations on the use of resveratrol","volume":"6","author":"Vang","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1111\/nure.12081-BIB0010|nure12081-cit-0010","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s12170-012-0289-2","article-title":"Resveratrol: effects on lipids and cardiovascular risk","volume":"7","author":"Cherniack","year":"2013","journal-title":"Curr Cardiovasc Risk Rep"},{"key":"10.1111\/nure.12081-BIB0011|nure12081-cit-0011","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1089\/jmf.2012.0025","article-title":"Resveratrol in cholesterol metabolism and atherosclerosis","volume":"15","author":"Voloshyna","year":"2012","journal-title":"J Med Food"},{"key":"10.1111\/nure.12081-BIB0012|nure12081-cit-0012","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.nutres.2012.07.002","article-title":"Resveratrol role in cardiovascular and metabolic health and potential mechanisms of action","volume":"32","author":"Xu","year":"2012","journal-title":"Nutr Res"},{"key":"10.1111\/nure.12081-BIB0013|nure12081-cit-0013","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s10741-011-9260-4","article-title":"Resveratrol in cardiovascular disease: what is known from current research?","volume":"17","author":"Wang","year":"2012","journal-title":"Heart Fail Rev"},{"key":"10.1111\/nure.12081-BIB0014|nure12081-cit-0014","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.bmc.2008.04.031","article-title":"Synthesis and biological evaluation of a library of resveratrol analogues as inhibitors of COX-1, COX-2 and NF-\u03baB","volume":"17","author":"Kang","year":"2009","journal-title":"Bioorg Med Chem"},{"key":"10.1111\/nure.12081-BIB0015|nure12081-cit-0015","first-page":"111","article-title":"Resveratrol reduces endothelial oxidative stress by modulating the gene expression of superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPx1) and NADPH oxidase subunit (Nox4)","volume":"60","author":"Spanier","year":"2009","journal-title":"J Physiol Pharmacol"},{"key":"10.1111\/nure.12081-BIB0016|nure12081-cit-0016","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.cmet.2011.10.002","article-title":"Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans","volume":"14","author":"Timmers","year":"2011","journal-title":"Cell Metab"},{"key":"10.1111\/nure.12081-BIB0017|nure12081-cit-0017","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1161\/ATVBAHA.109.187146","article-title":"Resveratrol improves endothelial function: role of TNF\u03b1 and vascular oxidative stress","volume":"29","author":"Zhang","year":"2009","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1111\/nure.12081-BIB0018|nure12081-cit-0018","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1365-2141.2007.06788.x","article-title":"Inhibitory mechanisms of resveratrol in platelet activation: pivotal roles of p38 MAPK and NO\/cyclic GMP","volume":"139","author":"Shen","year":"2007","journal-title":"Br J Haematol"},{"key":"10.1111\/nure.12081-BIB0019|nure12081-cit-0019","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.atherosclerosis.2009.05.017","article-title":"A new insight into resveratrol as an atheroprotective compound: inhibition of lipid peroxidation and enhancement of cholesterol efflux","volume":"207","author":"Berrougui","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1111\/nure.12081-BIB0020|nure12081-cit-0020","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3858\/emm.2009.41.3.020","article-title":"Resveratrol inhibits foam cell formation via NADPH oxidase 1-mediated reactive oxygen species and monocyte chemotactic protein-1","volume":"41","author":"Park","year":"2009","journal-title":"Exp Mol Med"},{"key":"10.1111\/nure.12081-BIB0021|nure12081-cit-0021","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/00001721-200408000-00001","article-title":"Effect of trans-resveratrol on the thrombogenicity and atherogenicity in apolipoprotein E-deficient and low-density lipoprotein receptor-deficient mice","volume":"15","author":"Fukao","year":"2004","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1111\/nure.12081-BIB0022|nure12081-cit-0022","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/S0024-3205(03)00469-7","article-title":"Hypolipidemic action of dietary resveratrol, a phytoalexin in grapes and red wine, in hepatoma-bearing rats","volume":"73","author":"Miura","year":"2003","journal-title":"Life Sci"},{"key":"10.1111\/nure.12081-BIB0023|nure12081-cit-0023","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.2337\/db12-0975","article-title":"High-dose resveratrol supplementation in obese men: an investigator-initiated, randomized, placebo-controlled clinical trial of substrate metabolism, insulin sensitivity, and body composition","volume":"62","author":"Poulsen","year":"2013","journal-title":"Diabetes"},{"key":"10.1111\/nure.12081-BIB0024|nure12081-cit-0024","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.nut.2012.07.006","article-title":"Oral resveratrol and calcium fructoborate supplementation in subjects with stable angina pectoris: effects on lipid profiles, inflammation markers, and quality of life","volume":"29","author":"Militaru","year":"2013","journal-title":"Nutrition"},{"key":"10.1111\/nure.12081-BIB0025|nure12081-cit-0025","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.nutres.2012.06.003","article-title":"Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus","volume":"32","author":"Bhatt","year":"2012","journal-title":"Nutr Res"},{"key":"10.1111\/nure.12081-BIB0026|nure12081-cit-0026","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/mnfr.201100673","article-title":"Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: a triple-blind, 6-month follow-up, placebo-controlled, randomized trial","volume":"56","author":"Tom\u00e9-Carneiro","year":"2012","journal-title":"Mol Nutr Food Res"},{"key":"10.1111\/nure.12081-BIB0027|nure12081-cit-0027","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3233\/CH-2011-1424","article-title":"Cardioprotection by resveratrol: a human clinical trial in patients with stable coronary artery disease","volume":"50","author":"Magyar","year":"2012","journal-title":"Clin Hemorheol Microcirc"},{"key":"10.1111\/nure.12081-BIB0028|nure12081-cit-0028","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.nutres.2011.09.028","article-title":"Modified resveratrol Longevinex improves endothelial function in adults with metabolic syndrome receiving standard treatment","volume":"31","author":"Fujitaka","year":"2011","journal-title":"Nutr Res"},{"key":"10.1111\/nure.12081-BIB0029|nure12081-cit-0029","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1210\/jc.2010-0482","article-title":"An antiinflammatory and reactive oxygen species suppressive effects of an extract of Polygonum cuspidatum containing resveratrol","volume":"95","author":"Ghanim","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1111\/nure.12081-BIB0030|nure12081-cit-0030","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.2174\/0929867311320100009","article-title":"Anti-inflammatory and antioxidant effects of resveratrol in healthy smokers a randomized, double-blind, placebo-controlled, cross-over trial","volume":"20","author":"Bo","year":"2013","journal-title":"Curr Med Chem"},{"key":"10.1111\/nure.12081-BIB0031|nure12081-cit-0031","doi-asserted-by":"crossref","first-page":"b2535","DOI":"10.1136\/bmj.b2535","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"339","author":"Moher","year":"2009","journal-title":"BMJ"},{"key":"10.1111\/nure.12081-BIB0032|nure12081-cit-0032","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","year":"2009"},{"key":"10.1111\/nure.12081-BIB0033|nure12081-cit-0033","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1089\/dna.2012.1947","article-title":"Does PPAR\u03b32 gene Pro12Ala polymorphism affect nonalcoholic fatty liver disease risk? Evidence from a meta-analysis","volume":"32","author":"Sahebkar","year":"2013","journal-title":"DNA Cell Biol"},{"key":"10.1111\/nure.12081-BIB0034|nure12081-cit-0034","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.0006-341X.2000.00455.x","article-title":"Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis","volume":"56","author":"Duval","year":"2000","journal-title":"Biometrics"},{"key":"10.1111\/nure.12081-BIB0035|nure12081-cit-0035","volume-title":"Comprehensive Meta-Analysis","author":"Borenstein","year":"2005"},{"key":"10.1111\/nure.12081-BIB0036|nure12081-cit-0036","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1017\/S0007114511000316","article-title":"Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients","volume":"106","author":"Brasny\u00f3","year":"2011","journal-title":"Br J Nutr"},{"key":"10.1111\/nure.12081-BIB0037|nure12081-cit-0037","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1158\/1055-9965.EPI-07-0022","article-title":"Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent","volume":"16","author":"Boocock","year":"2007","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1111\/nure.12081-BIB0038|nure12081-cit-0038","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.numecd.2010.03.003","article-title":"Acute resveratrol supplementation improves flow-mediated dilatation in overweight\/obese individuals with mildly elevated blood pressure","volume":"21","author":"Wong","year":"2011","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10.1111\/nure.12081-BIB0039|nure12081-cit-0039","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.mrgentox.2012.07.005","article-title":"Intake of a resveratrol-containing dietary supplement has no impact on DNA stability in healthy subjects","volume":"749","author":"Heger","year":"2012","journal-title":"Mutat Res"},{"key":"10.1111\/nure.12081-BIB0040|nure12081-cit-0040","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1093\/jn\/135.8.1911","article-title":"Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress","volume":"135","author":"Zern","year":"2005","journal-title":"J Nutr"},{"key":"10.1111\/nure.12081-BIB0041|nure12081-cit-0041","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.amjcard.2012.03.030","article-title":"One-year consumption of a grape nutraceutical containing resveratrol improves the inflammatory and fibrinolytic status of patients in primary prevention of cardiovascular disease","volume":"110","author":"Tom\u00e9-Carneiro","year":"2012","journal-title":"Am J Cardiol"},{"key":"10.1111\/nure.12081-BIB0042|nure12081-cit-0042","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1515\/CCLM.2008.118","article-title":"Free fatty acids as a cardiovascular risk factor","volume":"46","author":"Pilz","year":"2008","journal-title":"Clin Chem Lab Med"},{"key":"10.1111\/nure.12081-BIB0043|nure12081-cit-0043","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jchromb.2006.10.017","article-title":"Quantitation of trans-resveratrol and detection of its metabolites in human plasma and urine by high performance liquid chromatography","volume":"848","author":"Boocock","year":"2007","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10.1111\/nure.12081-BIB0044|nure12081-cit-0044","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1124\/dmd.104.000885","article-title":"High absorption but very low bioavailability of oral resveratrol in humans","volume":"32","author":"Walle","year":"2004","journal-title":"Drug Metab Dispos"},{"key":"10.1111\/nure.12081-BIB0045|nure12081-cit-0045","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1023\/A:1021414129280","article-title":"Human, rat and mouse metabolism of resveratrol","volume":"19","author":"Yu","year":"2002","journal-title":"Pharm Res"},{"key":"10.1111\/nure.12081-BIB0046|nure12081-cit-0046","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.cell.2006.11.013","article-title":"Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1\u03b1","volume":"127","author":"Lagouge","year":"2006","journal-title":"Cell"},{"key":"10.1111\/nure.12081-BIB0047|nure12081-cit-0047","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1124\/jpet.110.168724","article-title":"Resveratrol reverses endothelial nitric-oxide synthase uncoupling in apolipoprotein E knockout mice","volume":"335","author":"Xia","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1111\/nure.12081-BIB0048|nure12081-cit-0048","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/0140-6736(93)92472-6","article-title":"Inhibition of human LDL oxidation by resveratrol","volume":"341","author":"Frankel","year":"1993","journal-title":"Lancet"},{"key":"10.1111\/nure.12081-BIB0049|nure12081-cit-0049","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.yjmcc.2005.08.003","article-title":"Resveratrol enhances neovascularization in the infarcted rat myocardium through the induction of thioredoxin-1, heme oxygenase-1 and vascular endothelial growth factor","volume":"39","author":"Kaga","year":"2005","journal-title":"J Mol Cell Cardiol"},{"key":"10.1111\/nure.12081-BIB0050|nure12081-cit-0050","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3177\/jnsv.46.78","article-title":"Resveratrol attenuates ovariectomy-induced hypertension and bone loss in stroke-prone spontaneously hypertensive rats","volume":"46","author":"Mizutani","year":"2000","journal-title":"J Nutr Sci Vitaminol (Tokyo)"},{"key":"10.1111\/nure.12081-BIB0051|nure12081-cit-0051","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/ajh.2009.228","article-title":"Resveratrol prevents the development of pathological cardiac hypertrophy and contractile dysfunction in the SHR without lowering blood pressure","volume":"23","author":"Thandapilly","year":"2010","journal-title":"Am J Hypertens"},{"key":"10.1111\/nure.12081-BIB0052|nure12081-cit-0052","doi-asserted-by":"crossref","first-page":"429","DOI":"10.2174\/138920111794480552","article-title":"Resveratrol improves cardiovascular function in DOCA-salt hypertensive rats","volume":"12","author":"Chan","year":"2011","journal-title":"Curr Pharm Biotechnol"},{"key":"10.1111\/nure.12081-BIB0053|nure12081-cit-0053","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/s11883-012-0228-1","article-title":"Current concepts of the role of oxidized LDL receptors in atherosclerosis","volume":"14","author":"Goyal","year":"2012","journal-title":"Curr Atheroscler Rep"},{"key":"10.1111\/nure.12081-BIB0054|nure12081-cit-0054","doi-asserted-by":"crossref","first-page":"15","DOI":"10.6000\/1927-5951.2012.02.01.2","article-title":"Red dry wine modulates plasma cholesterol levels and cardiac enzymes in humans","volume":"2","author":"Peres","year":"2012","journal-title":"J Pharm Nutr Sci"},{"key":"10.1111\/nure.12081-BIB0055|nure12081-cit-0055","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/mnfr.201100336","article-title":"A moderate red wine intake improves blood lipid parameters and erythrocytes membrane fluidity in post myocardial infarct patients","volume":"56","author":"Rifler","year":"2012","journal-title":"Mol Nutr Food Res"},{"key":"10.1111\/nure.12081-BIB0056|nure12081-cit-0056","doi-asserted-by":"crossref","first-page":"545","DOI":"10.3109\/07853890.2011.588246","article-title":"Effects of moderate red wine consumption on liver fat and blood lipids: a prospective randomized study","volume":"43","author":"Kechagias","year":"2011","journal-title":"Ann Med"},{"key":"10.1111\/nure.12081-BIB0057|nure12081-cit-0057","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1590\/S0100-879X2005000900008","article-title":"The action of red wine and purple grape juice on vascular reactivity is independent of plasma lipids in hypercholesterolemic patients","volume":"38","author":"Coimbra","year":"2005","journal-title":"Braz J Med Biol Res"}],"container-title":["Nutrition Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nutritionreviews\/article-pdf\/71\/12\/822\/5190078\/nutritionreviews71-0822.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T16:46:49Z","timestamp":1716050809000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nutritionreviews\/article-lookup\/doi\/10.1111\/nure.12081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,1]]},"references-count":57,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,12]]}},"URL":"https:\/\/doi.org\/10.1111\/nure.12081","relation":{},"ISSN":["0029-6643"],"issn-type":[{"value":"0029-6643","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10,1]]}}}