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A novel, first\u2010in\u2010class calcium channel agonist that is selective for the types of voltage\u2010gated calcium channels that regulate transmitter release at neuromuscular synapses has recently been developed. This compound (GV\u201058) slows deactivation (closing) of the channel, resulting in a large increase in total calcium entry during motor nerve action potential activity. This new calcium channel agonist is currently being evaluated for the treatment of neuromuscular weakness. 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