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In particular,<jats:italic>de novo<\/jats:italic>development of donor\u2010specific antibodies (DSA) has been associated with acute and chronic antibody\u2010mediated graft rejection (AMR). Recently, methods for antibody detection have evolved remarkably from conventional cell\u2010based assays to advanced solid phase systems. These systems have revolutionized the art of defining clinically relevant antibodies that are directed toward a renal graft. While anti\u2010HLA DSAs have been widely associated with poor graft survival, the role of non\u2010HLA antibodies, particularly those directed against endothelial cells, is beginning to be realized. Appreciation of the mechanisms underlying T cell recognition of alloantigens has generated great interest in the use of synthetic peptides to prevent graft rejection. Hopefully, continued progress in unraveling the molecular mechanisms of graft rejection and posttransplant monitoring of antibodies using highly sensitive testing systems will prove beneficial to immunological risk assessment and early prediction of renal allograft failure.<\/jats:p>","DOI":"10.1111\/nyas.12034","type":"journal-article","created":{"date-parts":[[2013,2,5]],"date-time":"2013-02-05T20:19:36Z","timestamp":1360095576000},"page":"30-42","source":"Crossref","is-referenced-by-count":24,"title":["Clinical relevance of antibody development in renal transplantation"],"prefix":"10.1111","volume":"1283","author":[{"given":"Narinder K.","family":"Mehra","sequence":"first","affiliation":[{"name":"Department of Transplant Immunology and Immunogenetics All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamshaid","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Department of Transplant Immunology and Immunogenetics All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Baranwal","sequence":"additional","affiliation":[{"name":"Department of Transplant Immunology and Immunogenetics All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Goswami","sequence":"additional","affiliation":[{"name":"Department of Transplant Immunology and Immunogenetics All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurvinder","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Transplant Immunology and Immunogenetics All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,5]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"432","article-title":"Renal homotransplantation between identical twins","volume":"6","author":"Murray J.E.","year":"1955","journal-title":"Surgical Forum"},{"key":"e_1_2_6_3_1","volume-title":"The HLA Complex in Biology and Medicine: A Resource Book","author":"Mehra N.K.","year":"2010"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199203000-00011"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199408113310606"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2003.00135.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004121130"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000174338.97313.5a"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01644.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000170841"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01285.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2009.00912.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196904032801401"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/193724"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03283.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2741\/Benichou"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.11.7715"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000257960.07783.e3"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200107123450203"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000184444.93108.d1"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000269725.74189.b9"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.04.040186.001003"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2003.00072.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2005.00085.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2005.07.018"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02311205"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V10102208"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1993.187"},{"key":"e_1_2_6_29_1","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1681\/ASN.V133779","article-title":"Acute humoral rejection in kidney transplantation II. 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