{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T15:52:21Z","timestamp":1779205941597,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,5,7]],"date-time":"2013-05-07T00:00:00Z","timestamp":1367884800000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:p>Prophylactic vaccines based on tumor\u2010associated antigens (TAAs) have elicited concerns due to their potential toxicity. Because TAAs are considered self\u2010antigens, the prediction is that such vaccines will induce autoimmunity. While this has been observed in melanoma, where an antitumor immune response leads to vitiligo, autoimmunity has almost never been seen following vaccination with numerous other TAAs. We hypothesized that antigen choice determines outcome and have been working to identify TAAs whose expression differs between normal and tumor tissue, and thus could elicit antitumor immunity without autoimmunity. Studies on the epithelial TAA MUC1 have revealed that, compared to MUC1 on normal cells, tumors, premalignant lesions, and noncancerous pathologies affecting epithelial cells express abnormal MUC1, which is not a self\u2010antigen but rather an abnormal disease\u2010associated antigen (DAA). This distinction, which can be made for many known TAAs, has broad implications for the design and acceptance of preventative cancer vaccines.<\/jats:p>","DOI":"10.1111\/nyas.12108","type":"journal-article","created":{"date-parts":[[2013,5,7]],"date-time":"2013-05-07T15:48:16Z","timestamp":1367941696000},"page":"52-56","source":"Crossref","is-referenced-by-count":22,"title":["Preventing cancer by targeting abnormally expressed self\u2010antigens: MUC1 vaccines for prevention of epithelial adenocarcinomas"],"prefix":"10.1111","volume":"1284","author":[{"given":"Pamela L.","family":"Beatty","sequence":"first","affiliation":[{"name":"Department of Immunology University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivera J.","family":"Finn","sequence":"additional","affiliation":[{"name":"Department of Immunology University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgp263"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra072739"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1203486"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4161\/onci.18950"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-09-0194"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(04)82006-6"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.18.7159"},{"key":"e_1_2_8_9_1","first-page":"2908","article-title":"Cytotoxic T\u2010lymphocytes derived from patients with breast adenocarcinoma recognize an epitope present on the protein core of a mucin molecule preferentially expressed by malignant cells","volume":"51","author":"Jerome K.R.","year":"1991","journal-title":"Cancer Res"},{"key":"e_1_2_8_10_1","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.4049\/jimmunol.151.7.3693","article-title":"Cytotoxic T cells from ovarian malignant tumors can recognize polymorphic epithelial mucin core peptides","volume":"151","author":"Ioannides C.G.","year":"1993","journal-title":"J. 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