{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:18:34Z","timestamp":1790965114693,"version":"4.1.0"},"reference-count":96,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,4,23]],"date-time":"2013-04-23T00:00:00Z","timestamp":1366675200000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:p>Neuromyelitis optica (NMO) is a debilitating autoimmune inflammatory disease of the central nervous system (CNS) that is distinct from multiple sclerosis (MS). The discovery of NMO\u2010immunoglobulin G (IgG) in the serum of NMO\u2014but not MS\u2014patients was a breakthrough in defining diagnostic criteria for NMO. NMO\u2010IgG is an antibody directed against the astrocytic water channel protein aquaporin\u20104 (AQP4). While there is evidence that NMO\u2010IgG is also involved in mediating tissue damage in the CNS, many aspects of the pathogenic cascade in NMO remain to be determined. It is clear that antigen\u2010specific T cells contribute to the generation of NMO\u2010IgG in the peripheral immune compartment, as well as to the development of NMO lesions in the CNS. T helper 17 (Th17) cells, equipped both in providing B cell help and inducing tissue inflammation, may be involved in NMO development and pathogenesis. Here, we review immunologic aspects of NMO, placing recent findings in the biology of T\u2013B cell cooperation into perspective with autoimmunity of the CNS.<\/jats:p>","DOI":"10.1111\/nyas.12118","type":"journal-article","created":{"date-parts":[[2013,4,26]],"date-time":"2013-04-26T07:12:00Z","timestamp":1366960320000},"page":"57-66","source":"Crossref","is-referenced-by-count":83,"title":["Immunology of neuromyelitis optica: a T cell\u2013B cell collaboration"],"prefix":"10.1111","volume":"1283","author":[{"given":"Meike","family":"Mitsdoerffer","sequence":"first","affiliation":[{"name":"Department of Neurology, Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Kuchroo","sequence":"additional","affiliation":[{"name":"Center for Neurologic Diseases Brigham and Women's Hospital, Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Korn","sequence":"additional","affiliation":[{"name":"Department of Neurology, Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen  Munich Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy)  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,23]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"1033","article-title":"My\u00e9lite subaigu\u00eb compliqu\u00e9e de n\u00e9vrite optique","volume":"8","author":"Devic E.","year":"1894","journal-title":"Bull Med (Paris)"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.5.1107"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000216139.44259.74"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws109"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2009.06.014"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000254502.87233.9a"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.60.4.382"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70216-8"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17551-X"},{"key":"e_1_2_9_11_1","volume-title":"Neuromyelitis Optica","author":"Cloys D.E.","year":"1970"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410340211"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf151"},{"key":"e_1_2_9_14_1","first-page":"813","volume-title":"Greenfield's Neuropathology","author":"Prineas J.W.","year":"1997"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/62.1.25"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050304"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm047"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl371"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20081241"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318214332c"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1100648"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318200d80c"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.07.055"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI231"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/72256"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.72.2.262"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(00)00084-X"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-005-0984-x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.7.913"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000289761.64862.ce"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0764"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e32814f1c6b"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458506071174"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn240"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm062"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458508092811"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.7.964"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.03.016"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2010.02.007"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm027"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1109980108"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.297275"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e32832776f4"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq177"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21837"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21802"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.06.085"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp309"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027412"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2008.05302.x"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2620"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181a82621"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2007.17"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2008.01172.x"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31825644ff"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-011-0824-0"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458509350741"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458510382810"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23651"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2006.06.011"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016083"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015050"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.07.040189.001045"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri954"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132710"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/400_2008_17"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.23.021704.115707"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh453"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-5274-4"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2011.01.031"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathophys.2010.04.008"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009234107"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.06.001"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.10.015"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28334"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28330"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2012.314"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31826aac4e"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20090299"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.269"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.1.143"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000159399.81861.D5"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.11.noc80069"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.154"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.203"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.175"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22657"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.408716"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458506070732"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02897.x"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1159\/000227277"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458512439439"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458511431973"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.216"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1109997"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.1246"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.668"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnyas.12118","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nyas.12118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:34:13Z","timestamp":1695688453000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1111\/nyas.12118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":96,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1111\/nyas.12118"],"URL":"https:\/\/doi.org\/10.1111\/nyas.12118","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4]]}}}