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We recently completed a study that illustrates the use of unbiased genetic screens and murine cancer models to find therapeutic targets among complex genomic data. We genetically dissected the common deletion of chromosome 6q and identified the ephrin receptor A7 (<jats:italic>EPHA7<\/jats:italic>) as a tumor suppressor in lymphoma. Notably, <jats:italic>EPHA7<\/jats:italic> encodes a soluble splice variant that acts as an extrinsic tumor suppressor. Accordingly, we developed an antibody\u2010based strategy to specifically deliver <jats:italic>EPHA7<\/jats:italic> back to tumors that have lost this gene. Recent sequencing studies have implicated <jats:italic>EPHA7<\/jats:italic> in lung cancer and other tumors, suggesting a broader therapeutic potential for antibody\u2010mediated delivery of this tumor suppressor for cancer therapy. Together, our comprehensive approach provides new insights into cancer biology and may directly lead to the development of new cancer therapies.<\/jats:p>","DOI":"10.1111\/nyas.12120","type":"journal-article","created":{"date-parts":[[2013,5,15]],"date-time":"2013-05-15T14:39:08Z","timestamp":1368628748000},"page":"18-24","source":"Crossref","is-referenced-by-count":3,"title":["Functional genomics lead to new therapies in follicular lymphoma"],"prefix":"10.1111","volume":"1293","author":[{"given":"Elisa","family":"Oricchio","sequence":"first","affiliation":[{"name":"Cancer Biology &amp; Genetics Program, Memorial Sloan\u2010Kettering Cancer Center  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans\u2010Guido","family":"Wendel","sequence":"additional","affiliation":[{"name":"Cancer Biology &amp; Genetics Program, Memorial Sloan\u2010Kettering Cancer Center  New York New 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