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For more than 60 years, the prevention and treatment of these conditions have been dominated by oral vitamin K antagonists (such as warfarin) and the injectable heparins. Thrombosis can lead to several conditions, including deep vein thrombosis, pulmonary embolism, myocardial infarction, stroke, and\/or death. Prevention and treatment of thrombosis with an effective, convenient\u2010to\u2010use oral anticoagulant with a favorable safety profile is critical, especially in an aging society in which the risk of thrombosis, and the potential for bleeding complications, is increasing. Rivaroxaban acts to prevent and treat thrombosis by potently inhibiting coagulation Factor Xa in the blood. Factor Xa converts prothrombin to thrombin, which initiates the formation of blood clots by converting fibrinogen to clot\u2010forming fibrin and leads to platelet activation. After a large and novel clinical development program in over 75,000 patients to date, rivaroxaban has received approval for multiple indications in the United States, European Union, and other countries worldwide to prevent and treat several thrombosis\u2010mediated conditions. This review will highlight some of the unique aspects of the rivaroxaban development program.<\/jats:p>","DOI":"10.1111\/nyas.12136","type":"journal-article","created":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T19:49:39Z","timestamp":1369338579000},"page":"42-55","source":"Crossref","is-referenced-by-count":22,"title":["Rivaroxaban: a novel oral anticoagulant for the prevention and treatment of several thrombosis\u2010mediated conditions"],"prefix":"10.1111","volume":"1291","author":[{"given":"Troy C.","family":"Sarich","sequence":"first","affiliation":[{"name":"Janssen Research &amp; Development LLC  Raritan New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Peters","sequence":"additional","affiliation":[{"name":"Janssen Research &amp; Development LLC  Raritan New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott D.","family":"Berkowitz","sequence":"additional","affiliation":[{"name":"Bayer HealthCare Pharmaceuticals  Montville New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Misselwitz","sequence":"additional","affiliation":[{"name":"Bayer HealthCare Pharmaceuticals  Wuppertal Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher C.","family":"Nessel","sequence":"additional","affiliation":[{"name":"Janssen Research &amp; 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