{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:20:25Z","timestamp":1760217625800},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,2,3]],"date-time":"2014-02-03T00:00:00Z","timestamp":1391385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:p>Detection, treatment, and prevention of bone marrow diseases have long been the aims of experimental and clinical hematologists and mechanistically oriented toxicologists. Among these diseases is aplastic anemia, which manifests as the cessation of normal blood cell production; the leukemias, in contrast, feature the production of excessive hematologic cancer cells. Both diseases are associated with exposure to either industrial chemicals or cancer chemotherapeutic agents. Studies of hematopoietic bone marrow cells in culture have shown that the generation of circulating blood cells requires the interaction of hematopoietic stem cells (HSCs) with supporting marrow stromal cells; yet, isolation of HSCs from bone destroys the unique morphology of the marrow stroma in which the HSCs reside. Imaging techniques and related studies have made it possible to examine specific niches where HSCs may either initiate differentiation toward mature blood cells or reside in a dormant state awaiting a signal to begin differentiation. HSCs and related cells may be highly vulnerable to the mutagenic or toxic effects of drugs or other chemicals early in these processes. Additional studies are required to determine the mechanisms by which drug or chemical exposure may affect these cells and lead to either depression of bone marrow function or to leukemia.<\/jats:p>","DOI":"10.1111\/nyas.12333","type":"journal-article","created":{"date-parts":[[2014,2,4]],"date-time":"2014-02-04T17:58:33Z","timestamp":1391536713000},"page":"1-6","source":"Crossref","is-referenced-by-count":9,"title":["The bone marrow niche, stem cells, and leukemia: impact of drugs, chemicals, and the environment"],"prefix":"10.1111","volume":"1310","author":[{"given":"Robert","family":"Snyder","sequence":"first","affiliation":[{"name":"Ernest Mario School of Pharmacy The State University of New Jersey  Piscataway New Jersey"},{"name":"The Environmental and Occupational Health Sciences Institute, Rutgers The State University of New Jersey  Piscataway New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,3]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"Anderson N.2010.10 most common health diseases.www.livestrong.com\/article\/161780."},{"key":"e_1_2_5_3_1","first-page":"83","volume-title":"Drugs for Parasitic Infections","author":"Abromawicz M.","year":"2007"},{"key":"e_1_2_5_4_1","first-page":"549","volume-title":"Diseases of Workers. (1713) [Translated from the Latin text, De Morbis Artificum by W.C. Wright]. Published under the auspices of the New York Academy of Medicine","author":"Ramazzini B.","year":"1964"},{"key":"e_1_2_5_5_1","first-page":"352","volume-title":"Industrial Toxicology","author":"Hamilton A.","year":"1934"},{"key":"e_1_2_5_6_1","first-page":"1180","volume-title":"The Diseases of Occupations","author":"Hunter D.","year":"1962"},{"key":"e_1_2_5_7_1","first-page":"669","volume-title":"Inhalation Toxicology","author":"Snyder R.","year":"2006"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196410222711703"},{"key":"e_1_2_5_9_1","first-page":"59","volume-title":"Benzene Carcinogenicity","author":"Aksoy M.","year":"1988"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)90074-5"},{"key":"e_1_2_5_11_1","volume-title":"Milestones in Leukemia Research and Therapy","author":"Freireich E.J.","year":"1999"},{"key":"e_1_2_5_12_1","volume-title":"The Emperor of All Maladies. A Biography of Cancer","author":"Mukherjee S.","year":"2010"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2009.10.009"},{"key":"e_1_2_5_14_1","first-page":"622","volume-title":"Encyclopaedia Britannica","author":"Oesper R.O.","year":"1949"},{"key":"e_1_2_5_15_1","first-page":"60","volume-title":"Report on Carcinogens","author":"National Toxicology Program","year":"2011"},{"key":"e_1_2_5_16_1","unstructured":"USEPA.Summary and Analysis of the 2011 Gasoline Benzene Pre\u2010Compliance Reports (EPA\u2010420\u2010R\u201012\u2010007) January 2012."},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djs411"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.1-4-284"},{"key":"e_1_2_5_19_1","first-page":"336","article-title":"\u00dcber chronische Vegiftungen mit Steinkohlenteerbenzin: vier Todesf\u00e4lle","volume":"31","author":"Santesson C.G.","year":"1897","journal-title":"Arch. Hyg. Berl."},{"key":"e_1_2_5_20_1","first-page":"33","article-title":"A preliminary report of some cases of purpura haemorrhagica due to benzol poisoning","volume":"12","author":"Selling L.","year":"1910","journal-title":"Johns Hopkins Hosp. Rep."},{"key":"e_1_2_5_21_1","first-page":"83","article-title":"Benzol as a leucotoxin","volume":"17","author":"Selling L","year":"1916","journal-title":"Johns Hopkins Hosp. Rep."},{"key":"e_1_2_5_22_1","first-page":"425","article-title":"The action of benzol VI. Benzol vapor leucopenia (rabbit)","volume":"41","author":"Weiskotten H.G.","year":"1920","journal-title":"J. Med. Res."},{"key":"e_1_2_5_23_1","first-page":"345","article-title":"Sul problema delle mielopatie aplastische seudo\u2010 apalastische e leucemiche da benzolo","volume":"9","author":"Penati F.","year":"1938","journal-title":"Rass. Med. Ind."},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.961041339"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2007-0228"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-6611"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2005.03.023"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2009.12.013"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-301713"},{"key":"e_1_2_5_30_1","volume-title":"Drugs, Chemicals and Blood Dyscrasias","author":"Swanson M.","year":"1977"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnyas.12333","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nyas.12333","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T01:09:50Z","timestamp":1695604190000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1111\/nyas.12333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,3]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/nyas.12333"],"URL":"https:\/\/doi.org\/10.1111\/nyas.12333","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,3]]}}}