{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:46:23Z","timestamp":1790729183798,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,2,3]],"date-time":"2014-02-03T00:00:00Z","timestamp":1391385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:p>Wilson's disease causes disturbances of the central nervous system, affecting it both directly through copper toxicity and indirectly subject to a copper\u2010induced hepatopathy, resulting in morphological and physiological changes in brain structures that can be captured by means of magnetic resonance imaging (MRI), <jats:sup>123<\/jats:sup>I\u2010\u03b2\u2010CIT (2\u03b2\u2010carbomethoxy\u20103\u03b2 (4\u2010iodophenyl)tropane)\u2010SPECT (single photon emission computed tomography), <jats:sup>123<\/jats:sup>I\u2010IBZM (benzamide)\u2010SPECT and [<jats:sup>18<\/jats:sup>F]FDG \u2010PET (fluorodeoxyglucose\u2013positron emission tomography). MRI can reveal even slight morphological changes in non\u2010neurological Wilson's patients. More marked findings in neurological Wilson's patients become evident in T1\u2010 and T2\u2010weighted MRI. T1\u2010weighted MRI predominantly detects atrophic changes, whereas T2\u2010weighted MRI regularly records signal changes in the putamen. With the aid of these three nuclear\u2010medicine examinations, nigrostriatal and metabolic disturbances are identified in neurological Wilson's patients only. Sufficient decoppering therapy prevents progression and even tends to improve symptoms. A correlation between any of the imaging findings in patients with the genetic phenotype and the incidence of the most common mutation H1069Q (homozygote or compound heterozygote) or other mutations could not be substantiated.<\/jats:p>","DOI":"10.1111\/nyas.12343","type":"journal-article","created":{"date-parts":[[2014,2,4]],"date-time":"2014-02-04T18:03:41Z","timestamp":1391537021000},"page":"24-29","source":"Crossref","is-referenced-by-count":36,"title":["Morphological and functional imaging in neurological and non\u2010neurological Wilson's patients"],"prefix":"10.1111","volume":"1315","author":[{"given":"Wieland","family":"Hermann","sequence":"first","affiliation":[{"name":"Department of Neurology Paracelsus Clinic Zwickau  Zwickau Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02456569"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/34.4.295"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-3528(98)90133-6"},{"key":"e_1_2_8_5_1","first-page":"200","volume-title":"Leitlinie f\u00fcr Diagnostik und Therapie in der Neurologie","author":"Hermann W.","year":"2012"},{"key":"e_1_2_8_6_1","article-title":"Gepato\u2010tserebralnaya distrofia","author":"Konovalov N.V.","year":"1960","journal-title":"Moskva Medgiz"},{"key":"e_1_2_8_7_1","first-page":"136","article-title":"Untersuchungen zur Wilsonschen Erkrankung in der DDR. 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