{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T08:57:26Z","timestamp":1790499446354,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T00:00:00Z","timestamp":1392163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:p>Copper is an important cofactor in numerous biological processes in all living organisms. However, excessive copper can be extremely toxic, so it is vital that the copper level within a cell is tightly regulated. The damaging effect of copper is seen in several hereditary forms of copper toxicity in humans and animals. At present, Wilson's disease is the best\u2010described and best\u2010studied copper\u2010storage disorder in humans; it is caused by mutations in the<jats:italic>ATP7B<\/jats:italic>gene. In dogs, a mutation in the<jats:italic>COMMD1<\/jats:italic>gene has been found to be associated with copper toxicosis. Using a liver\u2010specific<jats:italic>Commd1<\/jats:italic>knockout mouse, the biological role of Commd1 in copper homeostasis has been confirmed. Yet, the exact mechanism by which COMMD1 regulates copper homeostasis is still unknown. Here, we give an overview of the current knowledge and perspectives on the molecular function of COMMD1 in copper homeostasis.<\/jats:p>","DOI":"10.1111\/nyas.12353","type":"journal-article","created":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T12:12:25Z","timestamp":1392207145000},"page":"6-14","source":"Crossref","is-referenced-by-count":35,"title":["Functional understanding of the versatile protein copper metabolism MURR1 domain 1 (COMMD1) in copper homeostasis"],"prefix":"10.1111","volume":"1314","author":[{"given":"Alina","family":"Fedoseienko","sequence":"first","affiliation":[{"name":"University of Groningen University Medical Center Groningen Molecular Genetics section Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Bartuzi","sequence":"additional","affiliation":[{"name":"University of Groningen University Medical Center Groningen Molecular Genetics section Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"van de Sluis","sequence":"additional","affiliation":[{"name":"University of Groningen University Medical Center Groningen Molecular Genetics section Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/5.10.1619"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0894-541"},{"key":"e_1_2_7_4_1","first-page":"13","article-title":"Chronic progressive hepatitis in Bedlington terriers associated with elevated liver copper concentrations","volume":"15","author":"Hardy R.M.","year":"1975","journal-title":"Minnesota Vet."},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.2460\/javma.1979.175.03.269","article-title":"Clinical, morphologic, and chemical studies on copper toxicosis of Bedlington Terriers","volume":"175","author":"Twedt D.C.","year":"1979","journal-title":"J. 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