{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:31:26Z","timestamp":1760549486696},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,3,10]],"date-time":"2014-03-10T00:00:00Z","timestamp":1394409600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:p>This paper reviews quantitative and qualitative studies conducted to identify changes in the characteristics of hematopoietic stem\/progenitor cells (HSCs\/HPCs) with or without radiation exposure. The numerical recovery of HSCs\/HPCs after radiation exposure is lower than for other types of cells, an effect that may depend on hierarchical ordering of generation age during blood cell differentiation, from primitive HSCs to various differentiated HPCs. Studies are in progress to evaluate gene expression in bone marrow cells and cells in the lineage\u2010negative, c\u2010Kit<jats:sup>+<\/jats:sup>, stem cell antigen<jats:sup>+<\/jats:sup> (LKS) fraction from 21\u2010month\u2010old mice, with or without radiation exposure. Preliminary data suggest that cell cycle\u2013related genes, that is, cyclin D1 (<jats:italic>Ccnd1<\/jats:italic>), phosphatidylinositol 3 kinase regulatory subunit polypeptide 1 (<jats:italic>PiK3r1<\/jats:italic>), and <jats:italic>Fyn<\/jats:italic>, are upregulated solely in the LKS fraction from 21\u2010month\u2010old mice irradiated at 6 weeks of age, compared with the LKS fraction from age\u2010matched nonirradiated control mice. Additional studies may provide evidence that the aging phenotype is exaggerated following exposure to ionizing radiation, specifically in the LKS fraction.<\/jats:p>","DOI":"10.1111\/nyas.12401","type":"journal-article","created":{"date-parts":[[2014,3,10]],"date-time":"2014-03-10T15:40:47Z","timestamp":1394466047000},"page":"69-73","source":"Crossref","is-referenced-by-count":7,"title":["Radiation\u2010induced, cell cycle\u2013related gene expression in aging hematopoietic stem cells: enigma of their recovery"],"prefix":"10.1111","volume":"1310","author":[{"given":"Yoko","family":"Hirabayashi","sequence":"first","affiliation":[{"name":"Division of Cellular and Molecular Toxicology Center for Biological Safety and Research National Institute of Health Sciences  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/HP.0b013e3182666d6f"},{"key":"e_1_2_7_3_1","first-page":"648","volume-title":"Proceedings of International Congress of Radiation Research (Japanese Association for Radiation Research (JARR))","author":"Cronkite E.P.","year":"1979"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553009014552481"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00411-012-0401-5"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-04-1418"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553000600857389"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.7.12.7417"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1667\/RR0260.1"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118349045.ch25"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1667\/RR2282.1"},{"issue":"3","key":"e_1_2_7_12_1","first-page":"489","article-title":"The p53\u2010deficient hemopoietic stem cells: their resistance to radiation\u2010apoptosis, but lasted transiently","volume":"11","author":"Hirabayashi Y.","year":"1997","journal-title":"Leukemia"},{"key":"e_1_2_7_13_1","first-page":"211","article-title":"Relative number and proliferation kinetics of hemopoietic stem cells in the mouse","volume":"5","author":"Siegers M.P.","year":"1979","journal-title":"Blood Cells"},{"key":"e_1_2_7_14_1","first-page":"667","article-title":"Stem cell (CFU\u2010s) proliferation in sublethally irradiated mice","volume":"15","author":"Necas E.","year":"1982","journal-title":"Cell Tissue Kinet."},{"key":"e_1_2_7_15_1","first-page":"53","article-title":"Thymidine suicide and hydroxyurea kill ratios accurately reflect the proliferative status of stem cells (CFU\u2010S)","volume":"17","author":"Necas E.","year":"1989","journal-title":"Exp. 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