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Both active RA and the use of high\u2010dose glucocorticoids (GCs) are associated with generalized bone loss and fractures, but it is well known that GCs have a strong immunosuppressive effect. With the introduction of tumor necrosis factor (TNF\u2010\u03b1)\u2010blockers and other biologics, clinical remission is a realistic target in approximately half of the early RA patients; the same seems to be true for the use of methotrexate with chronic low\u2010dose or initially high\u2010dose GCs. With the use of a treat\u2010to\u2010target strategy focusing on clinical remission or low disease activity in early RA patients, the negative effects of systemic inflammation on bone can be arrested, and both local bone loss (in the joints) and generalized bone loss at the spine and hips can be prevented.<\/jats:p>","DOI":"10.1111\/nyas.12430","type":"journal-article","created":{"date-parts":[[2014,4,16]],"date-time":"2014-04-16T17:44:03Z","timestamp":1397670243000},"page":"50-54","source":"Crossref","is-referenced-by-count":6,"title":["Are glucocorticoids harmful to bone in early rheumatoid arthritis?"],"prefix":"10.1111","volume":"1318","author":[{"given":"Willem F.","family":"Lems","sequence":"first","affiliation":[{"name":"Department of Rheumatology VU University Medical Center  Amsterdam the 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