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Besides the Bedlington terrier, where copper toxicosis is caused by a mutation in the<jats:italic>COMMD1<\/jats:italic>gene, more complex hereditary forms of copper\u2010associated hepatitis were recognized recently in other dog breeds. The Labrador retriever is one such breed, where an interplay between genetic susceptibility and exposure to copper lead to clinical copper toxicosis. Purebred dog populations are ideal for gene mapping studies, and because genes involved in copper metabolism are highly conserved across species, newly identified gene mutations in the dog may help unravel the genetic complexity of different human forms of copper toxicosis. Furthermore, increasing knowledge with respect to diagnosis and treatment strategies will benefit both species.<\/jats:p>","DOI":"10.1111\/nyas.12442","type":"journal-article","created":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T19:58:36Z","timestamp":1398283116000},"page":"42-48","source":"Crossref","is-referenced-by-count":20,"title":["New canine models of copper toxicosis: diagnosis, treatment, and genetics"],"prefix":"10.1111","volume":"1314","author":[{"given":"Hille","family":"Fieten","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences of Companion Animals Faculty of Veterinary Medicine Utrecht University Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis C.","family":"Penning","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences of Companion Animals Faculty of Veterinary Medicine Utrecht University Utrecht the 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