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Histopathology is significant for neuroepithelial damage with hair cell loss, basement membrane thickening, and perivascular microvascular damage. Cytochemical alterations are significant for altered AQP4 and AQP6 expression in the supporting cell, and altered cochlin and mitochondrial protein expression. Current developments include imaging techniques to determine the degree and presence of endolymphatic hydrops, and future studies will endeavor to correlate the observance of hydrops with clinical findings.<\/jats:p>","DOI":"10.1111\/nyas.12699","type":"journal-article","created":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T21:17:08Z","timestamp":1426195028000},"page":"49-57","source":"Crossref","is-referenced-by-count":73,"title":["Meniere's disease: histopathology, cytochemistry, and imaging"],"prefix":"10.1111","volume":"1343","author":[{"given":"Gail","family":"Ishiyama","sequence":"first","affiliation":[{"name":"Department of Neurology Reed Neurological Research Center David Geffen School of Medicine at UCLA  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan A.","family":"Lopez","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Department of Surgery David Geffen School of Medicine at UCLA  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali R.","family":"Sepahdari","sequence":"additional","affiliation":[{"name":"Department of Radiology David Geffen School of Medicine at UCLA  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Ishiyama","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Department of Surgery David Geffen School of Medicine at UCLA  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,12]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"29","article-title":"Sur une forme de surdite grave dependant d'une lesion de l'oreille interne","volume":"16","author":"Meniere P.","year":"1861","journal-title":"Gaz. 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