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By virtue of recent developments in clinical neurotology and neuroimaging, however, diagnosis of isolated central vestibulopathy is increasing. Here, we review five distinct syndromes of isolated central vestibular syndrome from lesions restricted to the vestibular nuclei, the nucleus prepositus hypoglossi, the flocculus, the tonsil, and the nodulus, and introduce a new vestibular syndrome from isolated involvement of the inferior cerebellar peduncle. Decreased responses to head impulses do not exclude a central lesion as a cause of isolated vestibular syndrome. Brain imaging, including diffusion\u2010weighted magnetic resonance imaging (MRI), may be falsely negative during the acute phase in patients with isolated vestibular syndrome because of a stroke. Central signs should be sought carefully in patients with isolated vertigo, even when the patients show the features of peripheral vestibulopathy and negative MRIs. Recognition of these isolated central vestibular syndromes would aid in defining the lesions responsible for various vestibular manifestations in central vestibulopathy.<\/jats:p>","DOI":"10.1111\/nyas.12712","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T15:57:14Z","timestamp":1425398234000},"page":"80-89","source":"Crossref","is-referenced-by-count":35,"title":["Isolated central vestibular syndrome"],"prefix":"10.1111","volume":"1343","author":[{"given":"Sung\u2010Hee","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Neurology Seoul National University College of Medicine, Seoul National University Bundang Hospital  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong\u2010Ho","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University College of Medicine, Seoul National University Bundang Hospital  Seoul 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