{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:09:38Z","timestamp":1791266978295,"version":"4.1.0"},"reference-count":192,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T00:00:00Z","timestamp":1430352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI 101093"],"award-info":[{"award-number":["AI 101093"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:p>Toll\u2010like receptors (TLRs) recognize common microbial or host\u2010derived macromolecules and have important roles in early activation of the immune system. Patients with primary immune deficiencies (PIDs) affecting TLR signaling can elucidate the importance of these proteins to the human immune system. Defects in interleukin\u20101 receptor\u2010associated kinase\u20104 and myeloid differentiation factor 88 (MyD88) lead to susceptibility to infections with bacteria, while mutations in nuclear factor\u2010\u03baB essential modulator (NEMO) and other downstream mediators generally induce broader susceptibility to bacteria, viruses, and fungi. In contrast, TLR3 signaling defects are specific for susceptibility to herpes simplex virus type 1 encephalitis. Other PIDs induce functional alterations of TLR signaling pathways, such as common variable immunodeficiency in which plasmacytoid dendritic cell defects enhance defective responses of B cells to shared TLR agonists. Dampening of TLR responses is seen for TLRs 2 and 4 in chronic granulomatous disease (CGD) and X\u2010linked agammaglobulinemia (XLA). Enhanced TLR responses, meanwhile, are seen for TLRs 5 and 9 in CGD, TLRs 4, 7\/8, and 9 in XLA, TLRs 2 and 4 in hyper IgE syndrome, and for most TLRs in adenosine deaminase deficiency.<\/jats:p>","DOI":"10.1111\/nyas.12763","type":"journal-article","created":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T20:26:06Z","timestamp":1430425566000},"page":"1-21","source":"Crossref","is-referenced-by-count":73,"title":["Toll\u2010like receptor signaling in primary immune deficiencies"],"prefix":"10.1111","volume":"1356","author":[{"given":"Paul J.","family":"Maglione","sequence":"first","affiliation":[{"name":"Division of Clinical Immunology, Departments of Medicine and Pediatrics Icahn School of Medicine at Mount Sinai  New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noa","family":"Simchoni","sequence":"additional","affiliation":[{"name":"Division of Clinical Immunology, Departments of Medicine and Pediatrics Icahn School of Medicine at Mount Sinai  New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Cunningham\u2010Rundles","sequence":"additional","affiliation":[{"name":"Division of Clinical Immunology, Departments of Medicine and Pediatrics Icahn School of Medicine at Mount Sinai  New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,30]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1863"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00461"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2941"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2007.02.007"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.5.3399"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-387664-5.00003-0"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000010"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1989.054.01.003"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2215"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0908451106"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.09.008"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.7.4641"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.47.33419"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2009.03.008"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.250476497"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.17.8729-8736.2002"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/41131"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.3.1435"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/80833"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2002.tb02727.x"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.4.1882"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/35099560"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1093616"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1093620"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/35047123"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1324266111"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1410293111"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1087262"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni986"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00733.x"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-014-1653-9"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2011.21"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0502-e131"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201242683"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2011.01088.x"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408363.2014.881317"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00509"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.11.050"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.02.012"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.04.047"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1081902"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1158298"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01182"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-07-587824"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070628"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e3181fd8ec3"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00001-11"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2006.044446"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2009.10.006"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3383"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-07-440776"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-01-0346"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00129-7"},{"key":"e_1_2_14_55_1","first-page":"255","article-title":"[Serum levels of IgG subclasses in the normal child. Evaluation by an immunoenzymatic method using monoclonal antibodies]","volume":"45","author":"Aucouturier P.","year":"1988","journal-title":"Arch. Fr. Pediatr."},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/148.1.131"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3028"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/85837"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI18714"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.01.762"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2003.11.013"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.08.018"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.06.052"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.08.047"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.05.032"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20060085"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1754"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2661"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705658"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2008.308"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-008-8085-2"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2014.157"},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-04-571265"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1914"},{"key":"e_1_2_14_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2013.04.003"},{"key":"e_1_2_14_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.10.001"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-02-141937"},{"key":"e_1_2_14_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.10.029"},{"key":"e_1_2_14_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2457"},{"key":"e_1_2_14_80_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1139522"},{"key":"e_1_2_14_81_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1128346"},{"key":"e_1_2_14_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.08.014"},{"key":"e_1_2_14_83_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI59259"},{"key":"e_1_2_14_84_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20111316"},{"key":"e_1_2_14_85_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101568"},{"key":"e_1_2_14_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11583"},{"key":"e_1_2_14_87_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2012.0140"},{"key":"e_1_2_14_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2284"},{"key":"e_1_2_14_89_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008300"},{"key":"e_1_2_14_90_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874210601105010190"},{"key":"e_1_2_14_91_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060360"},{"key":"e_1_2_14_92_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026198"},{"key":"e_1_2_14_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.22327"},{"key":"e_1_2_14_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2001.tb01586.x"},{"key":"e_1_2_14_95_1","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2002.1982"},{"key":"e_1_2_14_96_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.7.3451"},{"key":"e_1_2_14_97_1","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.11.3.625-626.2004"},{"key":"e_1_2_14_98_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00061703"},{"key":"e_1_2_14_99_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.375493"},{"key":"e_1_2_14_100_1","doi-asserted-by":"publisher","DOI":"10.1086\/514339"},{"key":"e_1_2_14_101_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir819"},{"key":"e_1_2_14_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23271"},{"key":"e_1_2_14_103_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102179"},{"key":"e_1_2_14_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2011.05.011"},{"key":"e_1_2_14_105_1","first-page":"200","article-title":"Promoter region polymorphism & expression profile of toll like receptor\u20103 (TLR\u20103) gene in chronic hepatitis C virus (HCV) patients from India","volume":"134","author":"Medhi S.","year":"2011","journal-title":"Indian J. Med. Res."},{"key":"e_1_2_14_106_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21491"},{"key":"e_1_2_14_107_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.042572-0"},{"key":"e_1_2_14_108_1","doi-asserted-by":"publisher","DOI":"10.1086\/344893"},{"key":"e_1_2_14_109_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.9.1028"},{"key":"e_1_2_14_110_1","doi-asserted-by":"publisher","DOI":"10.1086\/420830"},{"key":"e_1_2_14_111_1","first-page":"29","article-title":"Toll\u2010like receptor 4 Asp299Gly\/Thr399Ile polymorphisms are a risk factor for Candida bloodstream infection","volume":"17","author":"der Graaf C.A.","year":"2006","journal-title":"Eur. Cytokine Netw."},{"key":"e_1_2_14_112_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2003.01674.x"},{"key":"e_1_2_14_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2005.05.020"},{"key":"e_1_2_14_114_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-7-108"},{"key":"e_1_2_14_115_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32814e6b2d"},{"key":"e_1_2_14_116_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2010.01481.x"},{"key":"e_1_2_14_117_1","doi-asserted-by":"publisher","DOI":"10.2174\/157016210791111052"},{"key":"e_1_2_14_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2004.02.001"},{"key":"e_1_2_14_119_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.2009.00892.x"},{"key":"e_1_2_14_120_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010734"},{"key":"e_1_2_14_121_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20031220"},{"key":"e_1_2_14_122_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005990"},{"key":"e_1_2_14_123_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2007.00898.x"},{"key":"e_1_2_14_124_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026235"},{"key":"e_1_2_14_125_1","first-page":"162","article-title":"Primary immunodeficiency diseases: an update on the classification from the international union of immunological societies expert committee for primary immunodeficiency","volume":"5","author":"Al\u2010Herz W.","year":"2014","journal-title":"Front. Immunol"},{"key":"e_1_2_14_126_1","doi-asserted-by":"publisher","DOI":"10.1006\/clim.1999.4725"},{"key":"e_1_2_14_127_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.6.3932"},{"key":"e_1_2_14_128_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar1774"},{"key":"e_1_2_14_129_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12239"},{"key":"e_1_2_14_130_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2012.04620.x"},{"key":"e_1_2_14_131_1","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1996.0058"},{"key":"e_1_2_14_132_1","first-page":"362","article-title":"Three novel mammalian toll\u2010like receptors: gene structure, expression, and evolution","volume":"11","author":"Du X.","year":"2000","journal-title":"Eur. Cytokine Netw."},{"key":"e_1_2_14_133_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.3.1978"},{"key":"e_1_2_14_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2010.01.002"},{"key":"e_1_2_14_135_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0908560"},{"key":"e_1_2_14_136_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200107)31:7<2154::AID-IMMU2154>3.0.CO;2-U"},{"key":"e_1_2_14_137_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-011-9602-y"},{"key":"e_1_2_14_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2008.02.013"},{"key":"e_1_2_14_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.05.019"},{"key":"e_1_2_14_140_1","first-page":"207","article-title":"Quantitative and functional evaluation of innate immune responses in patients with common variable immunodeficiency","volume":"21","author":"Trujillo C.M.","year":"2011","journal-title":"J. Investig. Allergol. Clin. Immunol."},{"key":"e_1_2_14_141_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300213"},{"key":"e_1_2_14_142_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2012-0263OC"},{"key":"e_1_2_14_143_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300193"},{"key":"e_1_2_14_144_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318297427d"},{"key":"e_1_2_14_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2004.04.016"},{"key":"e_1_2_14_146_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636651"},{"key":"e_1_2_14_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2008.06.005"},{"key":"e_1_2_14_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.10.037"},{"key":"e_1_2_14_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.07.012"},{"key":"e_1_2_14_150_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-05-430959"},{"key":"e_1_2_14_151_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0604571103"},{"key":"e_1_2_14_152_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030348"},{"key":"e_1_2_14_153_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.9.6.722"},{"key":"e_1_2_14_154_1","doi-asserted-by":"publisher","DOI":"10.1038\/361226a0"},{"key":"e_1_2_14_155_1","doi-asserted-by":"crossref","first-page":"23857","DOI":"10.1016\/S0021-9258(19)51014-6","article-title":"B\u2010cell antigen receptor stimulation activates the human Bruton's tyrosine kinase, which is deficient in X\u2010linked agammaglobulinemia","volume":"269","author":"Weers M.","year":"1994","journal-title":"J. Biol. Chem."},{"key":"e_1_2_14_156_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.22.10606"},{"key":"e_1_2_14_157_1","doi-asserted-by":"crossref","first-page":"875","DOI":"10.4049\/jimmunol.163.2.875","article-title":"Delayed clearance of filarial infection and enhanced Th1 immunity due to modulation of macrophage APC functions in xid mice","volume":"163","author":"Mukhopadhyay S.","year":"1999","journal-title":"J. Immunol."},{"key":"e_1_2_14_158_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021845"},{"key":"e_1_2_14_159_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-012-9706-z"},{"key":"e_1_2_14_160_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.6.3635"},{"key":"e_1_2_14_161_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M301484200"},{"key":"e_1_2_14_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.10.009"},{"key":"e_1_2_14_163_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-037960"},{"key":"e_1_2_14_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2007.10.005"},{"key":"e_1_2_14_165_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.210"},{"key":"e_1_2_14_166_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2003.t01-1-02178.x"},{"key":"e_1_2_14_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.12.1085"},{"key":"e_1_2_14_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.01.037"},{"key":"e_1_2_14_169_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1299"},{"key":"e_1_2_14_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00297-8"},{"key":"e_1_2_14_171_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1118579109"},{"key":"e_1_2_14_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2010.06.011"},{"key":"e_1_2_14_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(99)70246-5"},{"key":"e_1_2_14_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2005.11.002"},{"key":"e_1_2_14_175_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06096"},{"key":"e_1_2_14_176_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-005-4183-2"},{"key":"e_1_2_14_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2005.04.009"},{"key":"e_1_2_14_178_1","doi-asserted-by":"publisher","DOI":"10.1159\/000115886"},{"key":"e_1_2_14_179_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa073687"},{"key":"e_1_2_14_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80005-9"},{"key":"e_1_2_14_181_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm976"},{"key":"e_1_2_14_182_1","doi-asserted-by":"publisher","DOI":"10.1007\/82_2010_51"},{"key":"e_1_2_14_183_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.9132"},{"key":"e_1_2_14_184_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.1.472"},{"key":"e_1_2_14_185_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.715439"},{"key":"e_1_2_14_186_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215683"},{"key":"e_1_2_14_187_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.1380050202"},{"key":"e_1_2_14_188_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-02-380105"},{"key":"e_1_2_14_189_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI61788"},{"key":"e_1_2_14_190_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200425524"},{"key":"e_1_2_14_191_1","doi-asserted-by":"publisher","DOI":"10.1586\/eri.10.158"},{"key":"e_1_2_14_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2014.05.004"},{"key":"e_1_2_14_193_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3493"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnyas.12763","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nyas.12763","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T02:51:00Z","timestamp":1695610260000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1111\/nyas.12763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,30]]},"references-count":192,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1111\/nyas.12763"],"URL":"https:\/\/doi.org\/10.1111\/nyas.12763","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,30]]}}}