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A fraction of B1a cells are maintained by self\u2010renewal for life, with the potential risk of dysregulated growth and progression to chronic lymphocytic leukemia (CLL)\/lymphoma during aging. In studies using the E\u03bc\u2010hTCL1 transgenic mouse system, it became clear that this B1a subset has a higher potential than other B cell subsets for progression to CLL. We have generated several autoreactive germline BCR gene models to compare B cells generated under conditions of natural exposure to autoantigen. 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