{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:05:01Z","timestamp":1791828301244,"version":"4.3.4"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,6,22]],"date-time":"2015-06-22T00:00:00Z","timestamp":1434931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR059130; R01CA176748"],"award-info":[{"award-number":["R01AR059130; R01CA176748"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["1I01BX001008"],"award-info":[{"award-number":["1I01BX001008"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R21CA176867"],"award-info":[{"award-number":["R21CA176867"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>The grape antioxidant resveratrol has been a topic of intense research for the past three decades. Resveratrol and other grape ingredients, as well as whole\u2010grape products, have shown considerable promise in health promotion and disease management. Phytochemically, whole grape represents a natural combination of resveratrol and other phytonutrients, as it contains several catechins, anthocyanins, polyphenols, and flavonols. Thus, whole grape products or specific combinations of grape constituents provide us with the possibility of synergistic interactions leading to improved efficacy. Recent research has suggested that whole\u2010grape products may help in maintaining heart health and protect against aging, aging\u2010associated diseases, neurodegeneration, and some cancers. On the basis of available recent literature, the grape fruit or whole\u2010grape products seem to be safer choices for better health and disease prevention. However, for advanced disease conditions, individual grape ingredients (such as resveratrol) or combinations of multiple ingredients, together with existing therapies, appear to be better approaches. Further clinical studies are needed to understand the benefits of grapes and their products in the prevention and management of specific diseases.<\/jats:p>","DOI":"10.1111\/nyas.12798","type":"journal-article","created":{"date-parts":[[2015,6,22]],"date-time":"2015-06-22T12:11:22Z","timestamp":1434975082000},"page":"150-160","source":"Crossref","is-referenced-by-count":121,"title":["Resveratrol, in its natural combination in whole grape, for health promotion and disease management"],"prefix":"10.1111","volume":"1348","author":[{"given":"Chandra K.","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Wisconsin  Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Purdue University  West Lafayette Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihal","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Wisconsin  Madison Wisconsin"},{"name":"William S. 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