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A biodegradable, sustained\u2010release implant, dexamethasone intravitreal implant 0.7 mg (Ozurdex), has been developed to deliver dexamethasone to target tissues in the posterior segment of the eye, minimizing systemic drug exposure and limiting side effects. The implant releases dexamethasone over a period of up to 6 months as the poly(<jats:sc>d<\/jats:sc>,<jats:sc>l<\/jats:sc>\u2010lactide\u2010co\u2010glycolide) polymer matrix of the implant is metabolized to carbon dioxide and water. The implant is placed in the vitreous of the eye with a single\u2010use applicator in a sutureless, office\u2010based procedure. Treatment with a single dexamethasone intravitreal implant in patients with noninfectious intermediate or posterior uveitis has been shown to produce significant improvements in intraocular inflammation and best\u2010corrected visual acuity with treatment benefit sustained for 6 months. Dexamethasone intravitreal implant has also been shown to reduce central retinal thickness and improve best\u2010corrected visual acuity in patients with macular edema of various etiologies. The implant has been approved for treatment of noninfectious uveitis involving the posterior segment, diabetic macular edema, and macular edema associated with branch and central retinal vein occlusion.<\/jats:p>","DOI":"10.1111\/nyas.12824","type":"journal-article","created":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T13:19:45Z","timestamp":1437571185000},"page":"1-12","source":"Crossref","is-referenced-by-count":50,"title":["Development of a dexamethasone intravitreal implant for the treatment of noninfectious posterior segment uveitis"],"prefix":"10.1111","volume":"1358","author":[{"given":"Scott M.","family":"Whitcup","sequence":"first","affiliation":[{"name":"Jules Stein Eye Institute David Geffen School of Medicine at University of California at Los Angeles  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Allergan, Inc  Irvine California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,22]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000078612"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.80.4.332"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2003.06.014"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1996.01100130585016"},{"key":"e_1_2_17_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2003.08.037"},{"key":"e_1_2_17_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/09273948.2012.658467"},{"key":"e_1_2_17_8_1","doi-asserted-by":"publisher","DOI":"10.1586\/ecp.12.55"},{"key":"e_1_2_17_9_1","first-page":"95","volume-title":"Uveitis: Fundamentals and Clinical Practice","author":"Nussenblatt R.B.","year":"2004"},{"key":"e_1_2_17_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000336676"},{"key":"e_1_2_17_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(02)01176-4"},{"key":"e_1_2_17_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c4976"},{"key":"e_1_2_17_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/08820538.2014.959203"},{"key":"e_1_2_17_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(00)00344-4"},{"key":"e_1_2_17_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200501000-00001"},{"key":"e_1_2_17_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2007.06.004"},{"key":"e_1_2_17_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200410000-00002"},{"key":"e_1_2_17_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/928123"},{"key":"e_1_2_17_19_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-11247"},{"key":"e_1_2_17_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-40-6-1073"},{"key":"e_1_2_17_21_1","unstructured":"The Merck Veterinary Manual. 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